Detailed information of TA system TA231627

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2402859..2403559
• Replicon: chromosome
• Accession: NZ_CP090687
• Organism: Burkholderia multivorans strain 2019Y60005016V

Toxin (Protein)

• Gene name: tad
• Uniprot ID: B9BQB7
• Locus tag: L0Y84_RS23970
• Protein ID: WP_006405634.1
• Coordinates: 2402859..2403236 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: B9BQB8
• Locus tag: L0Y84_RS23975
• Protein ID: WP_006405635.1
• Coordinates: 2403236..2403559 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y84_RS23945 (L0Y84_23945)	2398404..2398850	+	447	WP_006405630.1	VOC family protein	-
L0Y84_RS23950 (L0Y84_23950)	2398954..2400504	-	1551	WP_006398698.1	sodium:solute symporter family protein	-
L0Y84_RS23955 (L0Y84_23955)	2400501..2400734	-	234	WP_006398697.1	DUF3311 domain-containing protein	-
L0Y84_RS23960 (L0Y84_23960)	2400931..2401848	-	918	WP_006405631.1	spermidine synthase	-
L0Y84_RS23965 (L0Y84_23965)	2402076..2402330	+	255	WP_035488690.1	hypothetical protein	-
L0Y84_RS23970 (L0Y84_23970)	2402859..2403236	+	378	WP_006405634.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Y84_RS23975 (L0Y84_23975)	2403236..2403559	+	324	WP_006405635.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Y84_RS23980 (L0Y84_23980)	2403582..2404073	-	492	WP_006409760.1	DNA-deoxyinosine glycosylase	-
L0Y84_RS23985 (L0Y84_23985)	2404070..2404684	-	615	WP_006398690.1	chorismate lyase	-
L0Y84_RS23990 (L0Y84_23990)	2404693..2406591	-	1899	WP_006409758.1	molecular chaperone HtpG	-
L0Y84_RS23995 (L0Y84_23995)	2406750..2408210	-	1461	WP_006405639.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (23-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13564.63 Da
• Isoelectric Point: 9.7722

>T231627 WP_006405634.1 NZ_CP090687:2402859-2403236 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKHLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGLGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGEK

Nucleotide

• Length: 378 bp

>T231627 NZ_CP126937:1984035-1984289 [Escherichia coli O2:K1:H4]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11828.69 Da
• Isoelectric Point: 8.0686

>AT231627 WP_006405635.1 NZ_CP090687:2403236-2403559 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT231627 NZ_CP126937:1983787-1984038 [Escherichia coli O2:K1:H4]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Structures

Toxin

• AlphaFold DB: B9BQB7

Antitoxin

• AlphaFold DB: B9BQB8