Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1963464..1964084 Replicon chromosome
Accession NZ_CP090686
Organism Burkholderia multivorans strain 2019Y60005016V

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Y84_RS10770 Protein ID WP_012217495.1
Coordinates 1963464..1963781 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Y84_RS10775 Protein ID WP_006398012.1
Coordinates 1963785..1964084 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y84_RS10760 (L0Y84_10760) 1959999..1961432 - 1434 WP_006404214.1 aldehyde dehydrogenase family protein -
L0Y84_RS10765 (L0Y84_10765) 1961461..1963101 - 1641 WP_006398015.1 acetolactate synthase large subunit -
L0Y84_RS10770 (L0Y84_10770) 1963464..1963781 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Y84_RS10775 (L0Y84_10775) 1963785..1964084 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Y84_RS10780 (L0Y84_10780) 1964117..1965403 - 1287 WP_035487943.1 DUF445 domain-containing protein -
L0Y84_RS10785 (L0Y84_10785) 1965518..1966738 - 1221 WP_006411378.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Y84_RS10790 (L0Y84_10790) 1966728..1967054 - 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Y84_RS10795 (L0Y84_10795) 1967072..1967560 - 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Y84_RS10800 (L0Y84_10800) 1967575..1968846 - 1272 WP_006411366.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231624 WP_012217495.1 NZ_CP090686:1963464-1963781 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231624 NZ_CP126937:1022521-1022928 [Escherichia coli O2:K1:H4]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231624 WP_006398012.1 NZ_CP090686:1963785-1964084 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231624 NZ_CP126937:1022274-1022540 [Escherichia coli O2:K1:H4]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACATCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References