Detailed information of TA system TA231622

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1237128..1237662
• Replicon: chromosome
• Accession: NZ_CP090686
• Organism: Burkholderia multivorans strain 2019Y60005016V

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: L0Y84_RS07575
• Protein ID: WP_006411826.1
• Coordinates: 1237128..1237427 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: B9B0C2
• Locus tag: L0Y84_RS07580
• Protein ID: WP_006397060.1
• Coordinates: 1237417..1237662 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y84_RS07560 (L0Y84_07560)	1232705..1233832	-	1128	WP_006403536.1	VOC family protein	-
L0Y84_RS07565 (L0Y84_07565)	1234187..1235494	+	1308	WP_006411823.1	shikimate transporter	-
L0Y84_RS07570 (L0Y84_07570)	1235718..1237019	+	1302	WP_006403538.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
L0Y84_RS07575 (L0Y84_07575)	1237128..1237427	-	300	WP_006411826.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Y84_RS07580 (L0Y84_07580)	1237417..1237662	-	246	WP_006397060.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
L0Y84_RS07585 (L0Y84_07585)	1237802..1238572	+	771	WP_006403543.1	IclR family transcriptional regulator C-terminal domain-containing protein	-
L0Y84_RS07590 (L0Y84_07590)	1238611..1240911	-	2301	WP_006411821.1	ATP-dependent DNA helicase	-
L0Y84_RS07595 (L0Y84_07595)	1240908..1242611	-	1704	WP_006411824.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11585.15 Da
• Isoelectric Point: 9.3671

>T231622 WP_006411826.1 NZ_CP090686:c1237427-1237128 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWSYTYKRWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T231622 NZ_CP126937:745222-745596 [Escherichia coli O2:K1:H4]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCTCATCTCCCGTAACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTAAATGACACACCGTTCTCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCACCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8662.73 Da
• Isoelectric Point: 6.4604

>AT231622 WP_006397060.1 NZ_CP090686:c1237662-1237417 [Burkholderia multivorans]
MARNTSISLGDHLTEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Nucleotide

• Length: 246 bp

>AT231622 NZ_CP126937:744764-745132 [Escherichia coli O2:K1:H4]
GTGTCAGACACACTCCCCGGGACAACGCATCCCGACAACAACAACGATCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAAAGGGCTGACCTGCAAAGCCGACACCCTCGGTAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCAACATCCGAAACGAAAAAGTAA

Structures

Antitoxin

• AlphaFold DB: B9B0C2