231621

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 939350..941097 Replicon chromosome
Accession NZ_CP090686
Organism Burkholderia multivorans strain 2019Y60005016V

Toxin (Protein)


Gene name doc Uniprot ID B9BHC0
Locus tag L0Y84_RS06375 Protein ID WP_006403210.1
Coordinates 939350..940246 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B9AZJ2
Locus tag L0Y84_RS06380 Protein ID WP_006396780.1
Coordinates 940243..941097 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y84_RS06345 (L0Y84_06345) 934749..935828 - 1080 WP_006409825.1 porin -
L0Y84_RS06350 (L0Y84_06350) 936265..936582 + 318 WP_006396774.1 non-heme iron oxygenase ferredoxin subunit -
L0Y84_RS06355 (L0Y84_06355) 936584..936895 + 312 WP_006403207.1 hypothetical protein -
L0Y84_RS06360 (L0Y84_06360) 936943..938013 + 1071 WP_006403208.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
L0Y84_RS06365 (L0Y84_06365) 938006..938776 + 771 WP_006408452.1 SDR family oxidoreductase -
L0Y84_RS06370 (L0Y84_06370) 938804..939331 + 528 WP_006396778.1 cupin domain-containing protein -
L0Y84_RS06375 (L0Y84_06375) 939350..940246 + 897 WP_006403210.1 alpha/beta fold hydrolase Toxin
L0Y84_RS06380 (L0Y84_06380) 940243..941097 + 855 WP_006396780.1 IclR family transcriptional regulator Antitoxin
L0Y84_RS06385 (L0Y84_06385) 941094..941891 + 798 WP_006409174.1 SDR family oxidoreductase -
L0Y84_RS06390 (L0Y84_06390) 941884..943551 + 1668 WP_006403211.1 thiamine pyrophosphate-binding protein -
L0Y84_RS06395 (L0Y84_06395) 943544..944374 + 831 WP_006403212.1 aspartate dehydrogenase -
L0Y84_RS06400 (L0Y84_06400) 944436..945926 + 1491 WP_006403213.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, N-terminal

(23-71)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30544.80 Da        Isoelectric Point: 8.0446

>T231621 WP_006403210.1 NZ_CP090686:939350-940246 [Burkholderia multivorans]
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQQAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDAFCRQCDIERRAA

Download         Length: 897 bp

>T231621 NZ_CP126937:216078-216185 [Escherichia coli O2:K1:H4]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31176.75 Da        Isoelectric Point: 6.6558

>AT231621 WP_006396780.1 NZ_CP090686:940243-941097 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 855 bp

>AT231621 NZ_CP126937:c216021-215964 [Escherichia coli O2:K1:H4]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B9BHC0

Antitoxin

Source ID Structure
AlphaFold DB B9AZJ2

References