Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-StbC |
| Location | 801798..802387 | Replicon | chromosome |
| Accession | NZ_CP090686 | ||
| Organism | Burkholderia multivorans strain 2019Y60005016V | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | L0Y84_RS05740 | Protein ID | WP_006409935.1 |
| Coordinates | 801968..802387 (+) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | L0Y84_RS05735 | Protein ID | WP_174328801.1 |
| Coordinates | 801798..801971 (+) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Y84_RS05710 (L0Y84_05710) | 796880..797023 | - | 144 | WP_006409932.1 | hypothetical protein | - |
| L0Y84_RS05715 (L0Y84_05715) | 797612..797815 | + | 204 | WP_006403067.1 | hypothetical protein | - |
| L0Y84_RS05720 (L0Y84_05720) | 797829..798512 | - | 684 | WP_006409924.1 | Fe2+-dependent dioxygenase | - |
| L0Y84_RS05725 (L0Y84_05725) | 798509..799264 | - | 756 | WP_006403069.1 | tetratricopeptide repeat protein | - |
| L0Y84_RS05730 (L0Y84_05730) | 799268..801514 | - | 2247 | WP_006403070.1 | TonB-dependent siderophore receptor | - |
| L0Y84_RS05735 (L0Y84_05735) | 801798..801971 | + | 174 | WP_174328801.1 | plasmid stability protein | Antitoxin |
| L0Y84_RS05740 (L0Y84_05740) | 801968..802387 | + | 420 | WP_006409935.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| L0Y84_RS05745 (L0Y84_05745) | 802520..803815 | - | 1296 | WP_035487510.1 | aspartate carbamoyltransferase | - |
| L0Y84_RS05750 (L0Y84_05750) | 804048..804182 | + | 135 | WP_006409923.1 | entericidin A/B family lipoprotein | - |
| L0Y84_RS05755 (L0Y84_05755) | 804276..804851 | - | 576 | WP_006409927.1 | hypothetical protein | - |
| L0Y84_RS05760 (L0Y84_05760) | 805055..806005 | - | 951 | WP_172488721.1 | DMT family transporter | - |
| L0Y84_RS05765 (L0Y84_05765) | 806518..807312 | - | 795 | WP_006409930.1 | AraC family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 15146.38 Da Isoelectric Point: 5.2157
>T231620 WP_006409935.1 NZ_CP090686:801968-802387 [Burkholderia multivorans]
MILVDTNVIFEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AAGKAYARIRAHARAVGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWAS
MILVDTNVIFEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AAGKAYARIRAHARAVGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWAS
Download Length: 420 bp
>T231620 NZ_CP126937:215595-215702 [Escherichia coli O2:K1:H4]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6298.07 Da Isoelectric Point: 4.5184
>AT231620 WP_174328801.1 NZ_CP090686:801798-801971 [Burkholderia multivorans]
MHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTRTDPMSFE
MHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTRTDPMSFE
Download Length: 174 bp
>AT231620 NZ_CP126937:c215546-215481 [Escherichia coli O2:K1:H4]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|