Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 640213..641483 | Replicon | chromosome |
Accession | NZ_CP090686 | ||
Organism | Burkholderia multivorans strain 2019Y60005016V |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | L0Y84_RS05070 | Protein ID | WP_006410613.1 |
Coordinates | 640213..640791 (-) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | B9BS12 |
Locus tag | L0Y84_RS05075 | Protein ID | WP_006406126.1 |
Coordinates | 640926..641483 (-) | Length | 186 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L0Y84_RS05050 (L0Y84_05050) | 635501..636292 | + | 792 | WP_035947285.1 | enoyl-CoA hydratase | - |
L0Y84_RS05055 (L0Y84_05055) | 636289..637428 | + | 1140 | WP_006410588.1 | enoyl-CoA hydratase/isomerase family protein | - |
L0Y84_RS05060 (L0Y84_05060) | 637475..638395 | - | 921 | WP_006406123.1 | LysR family transcriptional regulator | - |
L0Y84_RS05065 (L0Y84_05065) | 638574..640112 | + | 1539 | WP_006410596.1 | MFS transporter | - |
L0Y84_RS05070 (L0Y84_05070) | 640213..640791 | - | 579 | WP_006410613.1 | HD domain-containing protein | Toxin |
L0Y84_RS05075 (L0Y84_05075) | 640926..641483 | - | 558 | WP_006406126.1 | helix-turn-helix transcriptional regulator | Antitoxin |
L0Y84_RS05080 (L0Y84_05080) | 641996..643399 | + | 1404 | WP_006406128.1 | hypothetical protein | - |
L0Y84_RS05085 (L0Y84_05085) | 643410..644030 | - | 621 | WP_006410617.1 | isochorismatase family cysteine hydrolase | - |
L0Y84_RS05090 (L0Y84_05090) | 644619..645062 | - | 444 | WP_223852633.1 | antibiotic biosynthesis monooxygenase | - |
L0Y84_RS05095 (L0Y84_05095) | 645162..646187 | - | 1026 | WP_006406131.1 | aldo/keto reductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21384.10 Da Isoelectric Point: 4.9434
>T231619 WP_006410613.1 NZ_CP090686:c640791-640213 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
APEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQT
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
APEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQT
Download Length: 579 bp
>T231619 NZ_CP126937:215113-215220 [Escherichia coli O2:K1:H4]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA
Antitoxin
Download Length: 186 a.a. Molecular weight: 20378.30 Da Isoelectric Point: 7.8341
>AT231619 WP_006406126.1 NZ_CP090686:c641483-640926 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATAERLLAAHLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATAERLLAAHLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL
Download Length: 558 bp
>AT231619 NZ_CP126937:c215056-214999 [Escherichia coli O2:K1:H4]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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