Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 640213..641483 Replicon chromosome
Accession NZ_CP090686
Organism Burkholderia multivorans strain 2019Y60005016V

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Y84_RS05070 Protein ID WP_006410613.1
Coordinates 640213..640791 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B9BS12
Locus tag L0Y84_RS05075 Protein ID WP_006406126.1
Coordinates 640926..641483 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y84_RS05050 (L0Y84_05050) 635501..636292 + 792 WP_035947285.1 enoyl-CoA hydratase -
L0Y84_RS05055 (L0Y84_05055) 636289..637428 + 1140 WP_006410588.1 enoyl-CoA hydratase/isomerase family protein -
L0Y84_RS05060 (L0Y84_05060) 637475..638395 - 921 WP_006406123.1 LysR family transcriptional regulator -
L0Y84_RS05065 (L0Y84_05065) 638574..640112 + 1539 WP_006410596.1 MFS transporter -
L0Y84_RS05070 (L0Y84_05070) 640213..640791 - 579 WP_006410613.1 HD domain-containing protein Toxin
L0Y84_RS05075 (L0Y84_05075) 640926..641483 - 558 WP_006406126.1 helix-turn-helix transcriptional regulator Antitoxin
L0Y84_RS05080 (L0Y84_05080) 641996..643399 + 1404 WP_006406128.1 hypothetical protein -
L0Y84_RS05085 (L0Y84_05085) 643410..644030 - 621 WP_006410617.1 isochorismatase family cysteine hydrolase -
L0Y84_RS05090 (L0Y84_05090) 644619..645062 - 444 WP_223852633.1 antibiotic biosynthesis monooxygenase -
L0Y84_RS05095 (L0Y84_05095) 645162..646187 - 1026 WP_006406131.1 aldo/keto reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21384.10 Da        Isoelectric Point: 4.9434

>T231619 WP_006410613.1 NZ_CP090686:c640791-640213 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
APEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQT

Download         Length: 579 bp

>T231619 NZ_CP126937:215113-215220 [Escherichia coli O2:K1:H4]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20378.30 Da        Isoelectric Point: 7.8341

>AT231619 WP_006406126.1 NZ_CP090686:c641483-640926 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATAERLLAAHLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Download         Length: 558 bp

>AT231619 NZ_CP126937:c215056-214999 [Escherichia coli O2:K1:H4]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B9BS12

References