Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1507233..1507691 Replicon chromosome
Accession NZ_CP090682
Organism Burkholderia multivorans strain 2019Y71417852IX

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L0Z03_RS17505 Protein ID WP_244131008.1
Coordinates 1507521..1507691 (-) Length 57 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag L0Z03_RS17500 Protein ID WP_105825892.1
Coordinates 1507233..1507517 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z03_RS17475 (L0Z03_17475) 1502878..1504299 - 1422 WP_105837109.1 FAD-binding oxidoreductase -
L0Z03_RS17480 (L0Z03_17480) 1504318..1504713 - 396 WP_088926186.1 DUF2069 domain-containing protein -
L0Z03_RS17485 (L0Z03_17485) 1504710..1505321 - 612 WP_105837110.1 NAD(P)H:quinone oxidoreductase -
L0Z03_RS17490 (L0Z03_17490) 1505466..1506794 + 1329 WP_039224705.1 YihY family inner membrane protein -
L0Z03_RS17495 (L0Z03_17495) 1506961..1507149 - 189 WP_105837111.1 hypothetical protein -
L0Z03_RS17500 (L0Z03_17500) 1507233..1507517 - 285 WP_105825892.1 putative addiction module antidote protein Antitoxin
L0Z03_RS17505 (L0Z03_17505) 1507521..1507691 - 171 WP_244131008.1 hypothetical protein Toxin
L0Z03_RS17510 (L0Z03_17510) 1508024..1508341 - 318 WP_006402097.1 DUF962 domain-containing protein -
L0Z03_RS17515 (L0Z03_17515) 1508502..1508957 + 456 WP_006402096.1 CBS domain-containing protein -
L0Z03_RS17520 (L0Z03_17520) 1509106..1511040 + 1935 WP_105778678.1 MFS transporter -
L0Z03_RS17525 (L0Z03_17525) 1511209..1512309 + 1101 WP_006413771.1 chorismate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-53)

Antitoxin

Uncharacterized protein HI1420

(5-90)


Sequences

Toxin        


Download         Length: 57 a.a.        Molecular weight: 6450.50 Da        Isoelectric Point: 8.4800

>T231617 WP_244131008.1 NZ_CP090682:c1507691-1507521 [Burkholderia multivorans]
VLDEGVCELKIDFGPGYRVYYVRRGEVVYLLLCGGDKSTQRKDVKRAVQMARELKE

Download         Length: 171 bp

>T231617 NZ_CP126936:79860-80009 [Escherichia coli O78:H4]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10013.45 Da        Isoelectric Point: 6.7229

>AT231617 WP_105825892.1 NZ_CP090682:c1507517-1507233 [Burkholderia multivorans]
MTNYTEFDAADYLDNDEAVAEFLAVAAEDPNPDVFLAAVAAVARARGMTKVAAAAGVGRVALHKALTPGAHPRYETVQKI
IRSLGLRMSFKVAH

Download         Length: 285 bp

>AT231617 NZ_CP126936:c79816-79755 [Escherichia coli O78:H4]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References