Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1776545..1777844 Replicon chromosome
Accession NZ_CP090681
Organism Burkholderia multivorans strain 2019Y71417852IX

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z03_RS07815 Protein ID WP_105835289.1
Coordinates 1777233..1777844 (+) Length 204 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z03_RS07810 Protein ID WP_039216965.1
Coordinates 1776545..1777102 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z03_RS07790 (L0Z03_07790) 1771712..1772308 - 597 WP_244131027.1 Crp/Fnr family transcriptional regulator -
L0Z03_RS07795 (L0Z03_07795) 1772865..1773497 + 633 WP_105835291.1 isochorismatase family cysteine hydrolase -
L0Z03_RS07800 (L0Z03_07800) 1773559..1774290 - 732 WP_012216547.1 ribonuclease T2 -
L0Z03_RS07805 (L0Z03_07805) 1774632..1776035 - 1404 WP_006396486.1 hypothetical protein -
L0Z03_RS07810 (L0Z03_07810) 1776545..1777102 + 558 WP_039216965.1 helix-turn-helix transcriptional regulator Antitoxin
L0Z03_RS07815 (L0Z03_07815) 1777233..1777844 + 612 WP_105835289.1 HD domain-containing protein Toxin
L0Z03_RS07820 (L0Z03_07820) 1777904..1779442 - 1539 WP_105810115.1 MFS transporter -
L0Z03_RS07825 (L0Z03_07825) 1779621..1780541 + 921 WP_006406123.1 LysR family transcriptional regulator -
L0Z03_RS07830 (L0Z03_07830) 1780588..1781727 - 1140 WP_035955456.1 enoyl-CoA hydratase/isomerase family protein -
L0Z03_RS07835 (L0Z03_07835) 1781724..1782515 - 792 WP_035955458.1 enoyl-CoA hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(6-189)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 204 a.a.        Molecular weight: 22627.45 Da        Isoelectric Point: 5.5913

>T231615 WP_105835289.1 NZ_CP090681:1777233-1777844 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMVLVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
ATEQAAHPEKNMHERDDLLTLTAALDPVLRDELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQTSSQTQTRTHRA

Download         Length: 612 bp

>T231615 NZ_CP126935:19128-19280 [Escherichia coli O78:H4]
ATGCCACAGCGAACATTTTTAATGATGTTGATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGGCTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20377.36 Da        Isoelectric Point: 8.5509

>AT231615 WP_039216965.1 NZ_CP090681:1776545-1777102 [Burkholderia multivorans]
MPDSPLHTPPLGPQLRRWRLLHRVKQSHAAALFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Download         Length: 558 bp

>AT231615 NZ_CP126935:c19078-19016 [Escherichia coli O78:H4]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References