Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1615608..1616299 Replicon chromosome
Accession NZ_CP090681
Organism Burkholderia multivorans strain 2019Y71417852IX

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z03_RS07160 Protein ID WP_065496260.1
Coordinates 1615608..1616063 (-) Length 152 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z03_RS07165 Protein ID WP_065496259.1
Coordinates 1616060..1616299 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z03_RS07135 (L0Z03_07135) 1610655..1611449 + 795 WP_105835364.1 AraC family transcriptional regulator -
L0Z03_RS07140 (L0Z03_07140) 1612041..1612991 + 951 WP_175848493.1 DMT family transporter -
L0Z03_RS07145 (L0Z03_07145) 1613187..1613756 + 570 WP_105835361.1 permease -
L0Z03_RS07150 (L0Z03_07150) 1613849..1613983 - 135 WP_006396654.1 entericidin A/B family lipoprotein -
L0Z03_RS07155 (L0Z03_07155) 1614216..1615511 + 1296 WP_035487510.1 aspartate carbamoyltransferase -
L0Z03_RS07160 (L0Z03_07160) 1615608..1616063 - 456 WP_065496260.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z03_RS07165 (L0Z03_07165) 1616060..1616299 - 240 WP_065496259.1 Arc family DNA-binding protein Antitoxin
L0Z03_RS07170 (L0Z03_07170) 1616604..1618850 + 2247 WP_012216643.1 TonB-dependent siderophore receptor -
L0Z03_RS07175 (L0Z03_07175) 1618854..1619609 + 756 WP_175848494.1 tetratricopeptide repeat protein -
L0Z03_RS07180 (L0Z03_07180) 1619606..1620289 + 684 WP_105835359.1 Fe2+-dependent dioxygenase -
L0Z03_RS07185 (L0Z03_07185) 1620303..1620506 - 204 WP_006396646.1 hypothetical protein -
L0Z03_RS07190 (L0Z03_07190) 1621095..1621238 + 144 WP_006409932.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 16209.56 Da        Isoelectric Point: 7.2060

>T231614 WP_065496260.1 NZ_CP090681:c1616063-1615608 [Burkholderia multivorans]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLAQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPVRQGIASK

Download         Length: 456 bp

>T231614 NZ_CP126934:c4874614-4874396 [Escherichia coli O78:H4]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8750.96 Da        Isoelectric Point: 5.1133

>AT231614 WP_065496259.1 NZ_CP090681:c1616299-1616060 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDFDIQRDKTPTDPMSFE

Download         Length: 240 bp

>AT231614 NZ_CP126934:c4875014-4874640 [Escherichia coli O78:H4]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References