Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 1480230..1481977 | Replicon | chromosome |
| Accession | NZ_CP090681 | ||
| Organism | Burkholderia multivorans strain 2019Y71417852IX | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | L0Z03_RS06535 | Protein ID | WP_105836409.1 |
| Coordinates | 1481081..1481977 (-) | Length | 299 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | B9AZJ2 |
| Locus tag | L0Z03_RS06530 | Protein ID | WP_006396780.1 |
| Coordinates | 1480230..1481084 (-) | Length | 285 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Z03_RS06510 (L0Z03_06510) | 1475405..1476895 | - | 1491 | WP_043278809.1 | aldehyde dehydrogenase | - |
| L0Z03_RS06515 (L0Z03_06515) | 1476953..1477783 | - | 831 | WP_105836412.1 | aspartate dehydrogenase | - |
| L0Z03_RS06520 (L0Z03_06520) | 1477776..1479443 | - | 1668 | WP_249458835.1 | thiamine pyrophosphate-binding protein | - |
| L0Z03_RS06525 (L0Z03_06525) | 1479436..1480233 | - | 798 | WP_006396781.1 | SDR family oxidoreductase | - |
| L0Z03_RS06530 (L0Z03_06530) | 1480230..1481084 | - | 855 | WP_006396780.1 | IclR family transcriptional regulator | Antitoxin |
| L0Z03_RS06535 (L0Z03_06535) | 1481081..1481977 | - | 897 | WP_105836409.1 | alpha/beta fold hydrolase | Toxin |
| L0Z03_RS06540 (L0Z03_06540) | 1481996..1482523 | - | 528 | WP_006396778.1 | cupin domain-containing protein | - |
| L0Z03_RS06545 (L0Z03_06545) | 1482551..1483321 | - | 771 | WP_006413827.1 | SDR family oxidoreductase | - |
| L0Z03_RS06550 (L0Z03_06550) | 1483314..1484384 | - | 1071 | WP_175848021.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| L0Z03_RS06555 (L0Z03_06555) | 1484432..1484743 | - | 312 | WP_006396775.1 | hypothetical protein | - |
| L0Z03_RS06560 (L0Z03_06560) | 1484745..1485062 | - | 318 | WP_006396774.1 | non-heme iron oxygenase ferredoxin subunit | - |
| L0Z03_RS06565 (L0Z03_06565) | 1485498..1486577 | + | 1080 | WP_039217461.1 | porin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 299 a.a. Molecular weight: 30543.77 Da Isoelectric Point: 8.0534
>T231613 WP_105836409.1 NZ_CP090681:c1481977-1481081 [Burkholderia multivorans]
MSVVDKRERDRTAAFGTLLERFPEQRCAAGAAGTIGYREAGAQHAGAALAVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDTFCRQCDIERRAA
MSVVDKRERDRTAAFGTLLERFPEQRCAAGAAGTIGYREAGAQHAGAALAVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDTFCRQCDIERRAA
Download Length: 897 bp
>T231613 NZ_CP126934:4198527-4198877 [Escherichia coli O78:H4]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 285 a.a. Molecular weight: 31176.75 Da Isoelectric Point: 6.6558
>AT231613 WP_006396780.1 NZ_CP090681:c1481084-1480230 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR
Download Length: 855 bp
>AT231613 NZ_CP126934:4198282-4198533 [Escherichia coli O78:H4]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|