Detailed information of TA system TA231611

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1170315..1170849
• Replicon: chromosome
• Accession: NZ_CP090681
• Organism: Burkholderia multivorans strain 2019Y71417852IX

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A1W0YQN7
• Locus tag: L0Z03_RS05285
• Protein ID: WP_035954873.1
• Coordinates: 1170550..1170849 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: L0Z03_RS05280
• Protein ID: WP_105836542.1
• Coordinates: 1170315..1170560 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z03_RS05265 (L0Z03_05265)	1165342..1167045	+	1704	WP_105836543.1	VRR-NUC domain-containing protein	-
L0Z03_RS05270 (L0Z03_05270)	1167042..1169342	+	2301	WP_175848076.1	ATP-dependent DNA helicase	-
L0Z03_RS05275 (L0Z03_05275)	1169405..1170175	-	771	WP_249458891.1	IclR family transcriptional regulator C-terminal domain-containing protein	-
L0Z03_RS05280 (L0Z03_05280)	1170315..1170560	+	246	WP_105836542.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
L0Z03_RS05285 (L0Z03_05285)	1170550..1170849	+	300	WP_035954873.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z03_RS05290 (L0Z03_05290)	1170957..1172258	-	1302	WP_006413706.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
L0Z03_RS05295 (L0Z03_05295)	1172540..1173157	+	618	WP_006397056.1	HNH endonuclease	-
L0Z03_RS05300 (L0Z03_05300)	1173192..1174499	-	1308	WP_039218025.1	shikimate transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-94)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11570.09 Da
• Isoelectric Point: 7.3154

>T231611 WP_035954873.1 NZ_CP090681:1170550-1170849 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLDQAERYIGELSAAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Nucleotide

• Length: 300 bp

>T231611 NZ_CP126934:c3345001-3344771 [Escherichia coli O78:H4]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8648.71 Da
• Isoelectric Point: 6.4592

>AT231611 WP_105836542.1 NZ_CP090681:1170315-1170560 [Burkholderia multivorans]
MARNTSISLGDHLTEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGDASGTPAPFDSQAFLARMRAKHA
G

Nucleotide

• Length: 246 bp

>AT231611 NZ_CP126934:c3344774-3344415 [Escherichia coli O78:H4]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Toxin

• AlphaFold DB: A0A1W0YQN7