Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 1031468..1032507 | Replicon | chromosome |
| Accession | NZ_CP090681 | ||
| Organism | Burkholderia multivorans strain 2019Y71417852IX | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | A0A1W0YRD2 |
| Locus tag | L0Z03_RS04645 | Protein ID | WP_060096181.1 |
| Coordinates | 1031932..1032507 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | - |
| Locus tag | L0Z03_RS04640 | Protein ID | WP_054316743.1 |
| Coordinates | 1031468..1031935 (+) | Length | 156 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Z03_RS04615 (L0Z03_04615) | 1026938..1028401 | + | 1464 | WP_105836663.1 | 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase | - |
| L0Z03_RS04620 (L0Z03_04620) | 1028444..1029292 | + | 849 | WP_012217098.1 | 3,4-dihydroxyphenylacetate 2,3-dioxygenase | - |
| L0Z03_RS04625 (L0Z03_04625) | 1029328..1029720 | + | 393 | WP_006403681.1 | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | - |
| L0Z03_RS04630 (L0Z03_04630) | 1029735..1030538 | + | 804 | WP_105842135.1 | 2-oxo-hepta-3-ene-1,7-dioic acid hydratase | - |
| L0Z03_RS04635 (L0Z03_04635) | 1030546..1031352 | + | 807 | WP_105836661.1 | 4-hydroxy-2-oxoheptanedioate aldolase | - |
| L0Z03_RS04640 (L0Z03_04640) | 1031468..1031935 | + | 468 | WP_054316743.1 | helix-turn-helix domain-containing protein | Antitoxin |
| L0Z03_RS04645 (L0Z03_04645) | 1031932..1032507 | + | 576 | WP_060096181.1 | PIN domain-containing protein | Toxin |
| L0Z03_RS04650 (L0Z03_04650) | 1032752..1033561 | - | 810 | WP_105836660.1 | helix-turn-helix transcriptional regulator | - |
| L0Z03_RS04655 (L0Z03_04655) | 1033657..1033908 | + | 252 | WP_039218251.1 | hypothetical protein | - |
| L0Z03_RS04660 (L0Z03_04660) | 1033987..1034952 | + | 966 | WP_105836659.1 | zinc-binding alcohol dehydrogenase family protein | - |
| L0Z03_RS04665 (L0Z03_04665) | 1035011..1035121 | - | 111 | Protein_930 | porin | - |
| L0Z03_RS04670 (L0Z03_04670) | 1035249..1035899 | + | 651 | WP_244130927.1 | hypothetical protein | - |
| L0Z03_RS04675 (L0Z03_04675) | 1036035..1037117 | - | 1083 | WP_006415045.1 | porin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21554.67 Da Isoelectric Point: 5.0551
>T231610 WP_060096181.1 NZ_CP090681:1031932-1032507 [Burkholderia multivorans]
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLAAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDEFVDNLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLAAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDEFVDNLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL
Download Length: 576 bp
>T231610 NZ_CP126934:c3323437-3322910 [Escherichia coli O78:H4]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA
Antitoxin
Download Length: 156 a.a. Molecular weight: 17581.02 Da Isoelectric Point: 6.1443
>AT231610 WP_054316743.1 NZ_CP090681:1031468-1031935 [Burkholderia multivorans]
MHHATTPDMILPVEREMQAAVEGQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELGKQAQALRMGYE
MHHATTPDMILPVEREMQAAVEGQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELGKQAQALRMGYE
Download Length: 468 bp
>AT231610 NZ_CP126934:c3323710-3323444 [Escherichia coli O78:H4]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|