Detailed information of TA system TA231608

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2484231..2484931
• Replicon: chromosome
• Accession: NZ_CP090680
• Organism: Burkholderia multivorans strain 2019Y71421880II

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: L0Z16_RS24980
• Protein ID: WP_059940738.1
• Coordinates: 2484231..2484608 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: B9BQB8
• Locus tag: L0Z16_RS24985
• Protein ID: WP_006405635.1
• Coordinates: 2484608..2484931 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z16_RS24955 (L0Z16_24955)	2479774..2480220	+	447	WP_006405630.1	VOC family protein	-
L0Z16_RS24960 (L0Z16_24960)	2480324..2481874	-	1551	WP_006398698.1	sodium:solute symporter family protein	-
L0Z16_RS24965 (L0Z16_24965)	2481871..2482104	-	234	WP_006398697.1	DUF3311 domain-containing protein	-
L0Z16_RS24970 (L0Z16_24970)	2482301..2483218	-	918	WP_105774162.1	spermidine synthase	-
L0Z16_RS24975 (L0Z16_24975)	2483447..2483701	+	255	WP_105774161.1	hypothetical protein	-
L0Z16_RS24980 (L0Z16_24980)	2484231..2484608	+	378	WP_059940738.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z16_RS24985 (L0Z16_24985)	2484608..2484931	+	324	WP_006405635.1	helix-turn-helix transcriptional regulator	Antitoxin
L0Z16_RS24990 (L0Z16_24990)	2484954..2485445	-	492	WP_070553236.1	DNA-deoxyinosine glycosylase	-
L0Z16_RS24995 (L0Z16_24995)	2485442..2486056	-	615	WP_006398690.1	chorismate lyase	-
L0Z16_RS25000 (L0Z16_25000)	2486065..2487963	-	1899	WP_006409758.1	molecular chaperone HtpG	-
L0Z16_RS25005 (L0Z16_25005)	2488122..2489582	-	1461	WP_006405639.1	PLP-dependent aminotransferase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (22-114)

Antitoxin

• Cro/C1-type helix-turn-helix domain (30-85)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13576.60 Da
• Isoelectric Point: 9.5719

>T231608 WP_059940738.1 NZ_CP090680:2484231-2484608 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGEK

Nucleotide

• Length: 378 bp

>T231608 NZ_CP126934:c2887871-2887575 [Escherichia coli O78:H4]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11828.69 Da
• Isoelectric Point: 8.0686

>AT231608 WP_006405635.1 NZ_CP090680:2484608-2484931 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Nucleotide

• Length: 324 bp

>AT231608 NZ_CP126934:c2887573-2887178 [Escherichia coli O78:H4]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Structures

Antitoxin

• AlphaFold DB: B9BQB8