Detailed information of TA system TA231607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2076293..2076849
• Replicon: chromosome
• Accession: NZ_CP090680
• Organism: Burkholderia multivorans strain 2019Y71421880II

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: L0Z16_RS23070
• Protein ID: WP_235488858.1
• Coordinates: 2076293..2076544 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0L8EUQ8
• Locus tag: L0Z16_RS23075
• Protein ID: WP_053244041.1
• Coordinates: 2076571..2076849 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z16_RS23035 (L0Z16_23035)	2072322..2073020	-	699	WP_249485538.1	hypothetical protein	-
L0Z16_RS23045 (L0Z16_23045)	2074389..2075297	-	909	WP_249485540.1	hypothetical protein	-
L0Z16_RS23050 (L0Z16_23050)	2075338..2075580	-	243	WP_105774341.1	hypothetical protein	-
L0Z16_RS23055 (L0Z16_23055)	2075607..2075792	-	186	WP_235488867.1	hypothetical protein	-
L0Z16_RS23060 (L0Z16_23060)	2075772..2076020	-	249	Protein_1915	XRE family transcriptional regulator	-
L0Z16_RS23065 (L0Z16_23065)	2076032..2076292	-	261	WP_053244039.1	hypothetical protein	-
L0Z16_RS23070 (L0Z16_23070)	2076293..2076544	-	252	WP_235488858.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L0Z16_RS23075 (L0Z16_23075)	2076571..2076849	-	279	WP_053244041.1	CopG family ribbon-helix-helix protein	Antitoxin
L0Z16_RS23080 (L0Z16_23080)	2077056..2077307	+	252	WP_121348300.1	hypothetical protein	-
L0Z16_RS23085 (L0Z16_23085)	2077430..2078161	+	732	WP_105774405.1	recombinase family protein	-
L0Z16_RS23090 (L0Z16_23090)	2078158..2078406	+	249	WP_181155630.1	hypothetical protein	-
L0Z16_RS23100 (L0Z16_23100)	2080026..2080774	-	749	Protein_1923	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2059251..2113626	54375
	-	inside	IScluster/Tn	-	-	2064995..2084021	19026

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9437.85 Da
• Isoelectric Point: 9.5302

>T231607 WP_235488858.1 NZ_CP090680:c2076544-2076293 [Burkholderia multivorans]
VLRLYRFLAPKDANAAQRAVQAIRAGVKILAHQPRIGRPVEDMEPEFREWLIDFGNGGYVALYRFDGENIAILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T231607 NZ_CP126934:2822350-2822727 [Escherichia coli O78:H4]
ATGAAAACATTACCCGACACGCATGTACGGGAGGCATCGCGCTGCCCGCCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATACGGTGAACTTTCTCGTTGAAAAATACGCACTGATACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGCGA
TAACTACAGAACGGTAAATAACATTACCCAGGGGAAACATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10747.06 Da
• Isoelectric Point: 5.6306

>AT231607 WP_053244041.1 NZ_CP090680:c2076849-2076571 [Burkholderia multivorans]
MATATSIKLDDELKGRVQHLAEARRRTSHWIMREAIAQYVEREEKREAFKQDALRAWEDYQRTGQHLTLEEADAWLAKLE
AGEDAELPKCHV

Nucleotide

• Length: 279 bp

>AT231607 NZ_CP126934:2821892-2822260 [Escherichia coli O78:H4]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCATGACCGTCCCTGGTGGGGACTACCCTGCACCGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAATGAAAAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A0L8EUQ8