231605

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 2036666..2037286 Replicon chromosome
Accession NZ_CP090678
Organism Burkholderia multivorans strain 2019Y71421880II

Toxin (Protein)


Gene name relE Uniprot ID A0A0H3KJN2
Locus tag L0Z16_RS08980 Protein ID WP_012217495.1
Coordinates 2036666..2036983 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID B9B269
Locus tag L0Z16_RS08985 Protein ID WP_006398012.1
Coordinates 2036987..2037286 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z16_RS08970 (L0Z16_08970) 2033270..2034703 - 1434 WP_105775342.1 aldehyde dehydrogenase family protein -
L0Z16_RS08975 (L0Z16_08975) 2034732..2036372 - 1641 WP_006398015.1 acetolactate synthase large subunit -
L0Z16_RS08980 (L0Z16_08980) 2036666..2036983 + 318 WP_012217495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Z16_RS08985 (L0Z16_08985) 2036987..2037286 + 300 WP_006398012.1 putative addiction module antidote protein Antitoxin
L0Z16_RS08990 (L0Z16_08990) 2037321..2038607 - 1287 WP_105775341.1 DUF445 domain-containing protein -
L0Z16_RS08995 (L0Z16_08995) 2038722..2039942 - 1221 WP_105775340.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Z16_RS09000 (L0Z16_09000) 2039932..2040258 - 327 WP_006404219.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Z16_RS09005 (L0Z16_09005) 2040276..2040764 - 489 WP_006398008.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Z16_RS09010 (L0Z16_09010) 2040779..2042050 - 1272 WP_105752935.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-102)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.94 Da        Isoelectric Point: 10.2349

>T231605 WP_012217495.1 NZ_CP090678:2036666-2036983 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWVVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Download         Length: 318 bp

>T231605 NZ_CP126934:c2565549-2565214 [Escherichia coli O78:H4]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10605.00 Da        Isoelectric Point: 6.6381

>AT231605 WP_006398012.1 NZ_CP090678:2036987-2037286 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT231605 NZ_CP126934:c2565797-2565549 [Escherichia coli O78:H4]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KJN2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KTI5

References