231601

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 769536..770227 Replicon chromosome
Accession NZ_CP090678
Organism Burkholderia multivorans strain 2019Y71421880II

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z16_RS03255 Protein ID WP_065496260.1
Coordinates 769772..770227 (+) Length 152 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z16_RS03250 Protein ID WP_065496259.1
Coordinates 769536..769775 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z16_RS03225 (L0Z16_03225) 764597..764740 - 144 WP_006409932.1 hypothetical protein -
L0Z16_RS03230 (L0Z16_03230) 765330..765533 + 204 WP_006403067.1 hypothetical protein -
L0Z16_RS03235 (L0Z16_03235) 765547..766230 - 684 WP_006409924.1 Fe2+-dependent dioxygenase -
L0Z16_RS03240 (L0Z16_03240) 766227..766982 - 756 WP_006403069.1 tetratricopeptide repeat protein -
L0Z16_RS03245 (L0Z16_03245) 766986..769231 - 2246 Protein_640 TonB-dependent siderophore receptor -
L0Z16_RS03250 (L0Z16_03250) 769536..769775 + 240 WP_065496259.1 Arc family DNA-binding protein Antitoxin
L0Z16_RS03255 (L0Z16_03255) 769772..770227 + 456 WP_065496260.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z16_RS03260 (L0Z16_03260) 770324..771619 - 1296 WP_035487510.1 aspartate carbamoyltransferase -
L0Z16_RS03265 (L0Z16_03265) 771850..771984 + 135 WP_059938951.1 entericidin A/B family lipoprotein -
L0Z16_RS03270 (L0Z16_03270) 772079..772654 - 576 WP_105774937.1 permease -
L0Z16_RS03275 (L0Z16_03275) 772850..773800 - 951 WP_088929831.1 DMT family transporter -
L0Z16_RS03280 (L0Z16_03280) 774057..774851 - 795 WP_059938960.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 16209.56 Da        Isoelectric Point: 7.2060

>T231601 WP_065496260.1 NZ_CP090678:769772-770227 [Burkholderia multivorans]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLAQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPVRQGIASK

Download         Length: 456 bp

>T231601 NZ_CP126934:c1724982-1724728 [Escherichia coli O78:H4]
GTGAAACTAATCTGGTCTGAGGAGTCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CATTGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8750.96 Da        Isoelectric Point: 5.1133

>AT231601 WP_065496259.1 NZ_CP090678:769536-769775 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDFDIQRDKTPTDPMSFE

Download         Length: 240 bp

>AT231601 NZ_CP126934:c1725230-1724979 [Escherichia coli O78:H4]
ATGCGTACAATTAGCTACAGCGAAGCGCGCCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References