Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2352615..2353841 Replicon chromosome
Accession NZ_CP090677
Organism Burkholderia cenocepacia strain 2019Y71443953II

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Y99_RS31475 Protein ID WP_205671284.1
Coordinates 2353260..2353841 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Y99_RS31470 Protein ID WP_006483170.1
Coordinates 2352615..2353181 (+) Length 189 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y99_RS31445 (L0Y99_31445) 2348008..2348643 + 636 WP_205671283.1 isochorismatase family cysteine hydrolase -
L0Y99_RS31450 (L0Y99_31450) 2348669..2349400 - 732 WP_006498851.1 ribonuclease T2 -
L0Y99_RS31455 (L0Y99_31455) 2349436..2350020 + 585 WP_227739690.1 OsmC family protein -
L0Y99_RS31460 (L0Y99_31460) 2350099..2350671 - 573 WP_006498849.1 hypothetical protein -
L0Y99_RS31465 (L0Y99_31465) 2350765..2352168 - 1404 WP_077056620.1 hypothetical protein -
L0Y99_RS31470 (L0Y99_31470) 2352615..2353181 + 567 WP_006483170.1 helix-turn-helix transcriptional regulator Antitoxin
L0Y99_RS31475 (L0Y99_31475) 2353260..2353841 + 582 WP_205671284.1 HD domain-containing protein Toxin
L0Y99_RS31480 (L0Y99_31480) 2354510..2355268 + 759 WP_205671285.1 DUF3658 domain-containing protein -
L0Y99_RS31485 (L0Y99_31485) 2355477..2356667 + 1191 WP_060263806.1 efflux RND transporter periplasmic adaptor subunit -
L0Y99_RS31490 (L0Y99_31490) 2356670..2358703 + 2034 WP_048986896.1 MacB family efflux pump subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2347139..2355268 8129


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21339.91 Da        Isoelectric Point: 4.9572

>T231599 WP_205671284.1 NZ_CP090677:2353260-2353841 [Burkholderia cenocepacia]
MNPDTIRARLDFLRDAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGVDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRAARDEIVALWDEYEAATSPEARAAKALDKLETILQHNQGNNPPDFDYAFNLGY
GRRYTDAAPLFSAIREIVDVDTQRRIDAGGQRA

Download         Length: 582 bp

>T231599 NZ_CP126934:c1527321-1527218 [Escherichia coli O78:H4]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 189 a.a.        Molecular weight: 20583.56 Da        Isoelectric Point: 10.7753

>AT231599 WP_006483170.1 NZ_CP090677:2352615-2353181 [Burkholderia cenocepacia]
MPHPPLHPSSLGPQLKRWRALHRVKQSHAAELFRVAQSTISRWEAGLQQMSPAERATAERLLAARLDSAGDHALARLIAG
STGRMHLVCDLTHRLLASSPARAAEFSRPLSTLLGASLWRYATPEIARMEAALDPLGWYDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAVRLVETLDAH

Download         Length: 567 bp

>AT231599 NZ_CP126934:1527217-1527451 [Escherichia coli O78:H4]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References