Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1995639..1997431 Replicon chromosome
Accession NZ_CP090677
Organism Burkholderia cenocepacia strain 2019Y71443953II

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag L0Y99_RS29845 Protein ID WP_205670554.1
Coordinates 1996535..1997431 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A364H4C6
Locus tag L0Y99_RS29840 Protein ID WP_006496928.1
Coordinates 1995639..1996496 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y99_RS29820 (L0Y99_29820) 1990802..1992292 - 1491 WP_006487205.1 aldehyde dehydrogenase -
L0Y99_RS29825 (L0Y99_29825) 1992365..1993192 - 828 WP_034202181.1 aspartate dehydrogenase -
L0Y99_RS29830 (L0Y99_29830) 1993185..1994852 - 1668 WP_205670553.1 thiamine pyrophosphate-binding protein -
L0Y99_RS29835 (L0Y99_29835) 1994845..1995642 - 798 WP_034202180.1 SDR family oxidoreductase -
L0Y99_RS29840 (L0Y99_29840) 1995639..1996496 - 858 WP_006496928.1 IclR family transcriptional regulator Antitoxin
L0Y99_RS29845 (L0Y99_29845) 1996535..1997431 - 897 WP_205670554.1 alpha/beta fold hydrolase Toxin
L0Y99_RS29850 (L0Y99_29850) 1997450..1997977 - 528 WP_006489904.1 cupin domain-containing protein -
L0Y99_RS29855 (L0Y99_29855) 1998012..1998782 - 771 WP_080322526.1 SDR family oxidoreductase -
L0Y99_RS29860 (L0Y99_29860) 1998775..1999845 - 1071 WP_006489909.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
L0Y99_RS29865 (L0Y99_29865) 1999900..2000211 - 312 WP_006489911.1 hypothetical protein -
L0Y99_RS29870 (L0Y99_29870) 2000213..2000530 - 318 WP_006489883.1 non-heme iron oxygenase ferredoxin subunit -
L0Y99_RS29875 (L0Y99_29875) 2000975..2002054 + 1080 WP_006489902.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30585.83 Da        Isoelectric Point: 7.7324

>T231598 WP_205670554.1 NZ_CP090677:c1997431-1996535 [Burkholderia cenocepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWLRQLDTLGASRRVLAW
DAPGYGVSTPVHGVSPAAADYAAALNAWLEALGIERCVLVGHSLGAIIAGGLARVTPARIAGLLLVSPAGGYGSAPAETR
EARRDARLAMLAELGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAAYSALIDSFCRQCDTQWGLA

Download         Length: 897 bp

>T231598 NZ_CP126934:c1146288-1144966 [Escherichia coli O78:H4]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31371.86 Da        Isoelectric Point: 6.5061

>AT231598 WP_006496928.1 NZ_CP090677:c1996496-1995639 [Burkholderia cenocepacia]
MSEPLQQNESENAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGVLNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT231598 NZ_CP126934:c1146554-1146288 [Escherichia coli O78:H4]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A364H4C6

References