Detailed information of TA system TA231597

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1751644..1752283
• Replicon: chromosome
• Accession: NZ_CP090677
• Organism: Burkholderia cenocepacia strain 2019Y71443953II

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L0Y99_RS28760
• Protein ID: WP_006481544.1
• Coordinates: 1751644..1752060 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A364H554
• Locus tag: L0Y99_RS28765
• Protein ID: WP_006481537.1
• Coordinates: 1752047..1752283 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y99_RS28735 (L0Y99_28735)	1746751..1747851	-	1101	WP_062885552.1	nitronate monooxygenase	-
L0Y99_RS28740 (L0Y99_28740)	1747848..1748768	-	921	WP_006481536.1	enoyl-CoA hydratase	-
L0Y99_RS28745 (L0Y99_28745)	1748777..1749574	-	798	WP_006481539.1	hypothetical protein	-
L0Y99_RS28750 (L0Y99_28750)	1749585..1750478	-	894	WP_062885556.1	CoA-transferase	-
L0Y99_RS28755 (L0Y99_28755)	1750488..1751384	-	897	WP_058903174.1	VOC family protein	-
L0Y99_RS28760 (L0Y99_28760)	1751644..1752060	-	417	WP_006481544.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Y99_RS28765 (L0Y99_28765)	1752047..1752283	-	237	WP_006481537.1	DNA-binding protein	Antitoxin
L0Y99_RS28770 (L0Y99_28770)	1752776..1754002	+	1227	WP_205670521.1	acyltransferase	-
L0Y99_RS28775 (L0Y99_28775)	1754013..1754690	-	678	WP_077176171.1	hypothetical protein	-
L0Y99_RS28780 (L0Y99_28780)	1755339..1756112	-	774	WP_077189415.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15402.64 Da
• Isoelectric Point: 6.8818

>T231597 WP_006481544.1 NZ_CP090677:c1752060-1751644 [Burkholderia cenocepacia]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWLTMILSGYAPNI
LPVDVETGQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFE

Nucleotide

• Length: 417 bp

>T231597 NZ_CP126934:c951889-951695 [Escherichia coli O78:H4]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8710.78 Da
• Isoelectric Point: 5.0916

>AT231597 WP_006481537.1 NZ_CP090677:c1752283-1752047 [Burkholderia cenocepacia]
MANLLVRNVDDTLVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPEVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT231597 NZ_CP126934:951518-951696 [Escherichia coli O78:H4]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Antitoxin

• AlphaFold DB: A0A364H554