Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1236029..1236675 Replicon chromosome
Accession NZ_CP090677
Organism Burkholderia cenocepacia strain 2019Y71443953II

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Y99_RS26505 Protein ID WP_109342384.1
Coordinates 1236268..1236675 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B4EGU8
Locus tag L0Y99_RS26500 Protein ID WP_006491146.1
Coordinates 1236029..1236271 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y99_RS26485 (L0Y99_26485) 1232024..1233430 + 1407 WP_111441417.1 aspartate ammonia-lyase -
L0Y99_RS26490 (L0Y99_26490) 1233508..1235013 + 1506 WP_006491141.1 amino acid permease -
L0Y99_RS26495 (L0Y99_26495) 1235087..1235770 - 684 WP_111441416.1 phospholipase -
L0Y99_RS26500 (L0Y99_26500) 1236029..1236271 + 243 WP_006491146.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L0Y99_RS26505 (L0Y99_26505) 1236268..1236675 + 408 WP_109342384.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Y99_RS26510 (L0Y99_26510) 1236792..1236980 - 189 WP_240465729.1 hypothetical protein -
L0Y99_RS26515 (L0Y99_26515) 1237077..1239452 + 2376 WP_111441414.1 MCP four helix bundle domain-containing protein -
L0Y99_RS26520 (L0Y99_26520) 1239475..1240203 + 729 WP_111441422.1 methyl-accepting chemotaxis protein -
L0Y99_RS26525 (L0Y99_26525) 1240200..1240781 + 582 WP_069353548.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14945.06 Da        Isoelectric Point: 6.3763

>T231596 WP_109342384.1 NZ_CP090677:1236268-1236675 [Burkholderia cenocepacia]
MKFLLDTNAVIAILKGEPAILARLHAWHPADFGIPAIVAHELYYGAYKSQRAAANVARVDALQFEVVSFDTEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARHLVLVTHNVREFERVPRLQFEDWLAEPRAD

Download         Length: 408 bp

>T231596 NZ_CP126934:c814155-814048 [Escherichia coli O78:H4]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.02 Da        Isoelectric Point: 5.0197

>AT231596 WP_006491146.1 NZ_CP090677:1236029-1236271 [Burkholderia cenocepacia]
MDTAKLFKHGGSQAVRLPKDFRFDTAEVRIRRHGAAVILEPMPQDWAWLAPLIGPVDADFEAAATTQPSAQERSGLDVFE

Download         Length: 243 bp

>AT231596 NZ_CP126934:814202-814268 [Escherichia coli O78:H4]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4EGU8

References