Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 877048..877689 Replicon chromosome
Accession NZ_CP090677
Organism Burkholderia cenocepacia strain 2019Y71443953II

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L0Y99_RS24970 Protein ID WP_276209001.1
Coordinates 877351..877689 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag L0Y99_RS24965 Protein ID WP_062885379.1
Coordinates 877048..877347 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y99_RS24940 (L0Y99_24940) 872268..873539 + 1272 WP_205670708.1 anthranilate 1,2-dioxygenase large subunit AndAc -
L0Y99_RS24945 (L0Y99_24945) 873555..874031 + 477 WP_006490977.1 anthranilate 1,2-dioxygenase small subunit AndAd -
L0Y99_RS24950 (L0Y99_24950) 874067..874393 + 327 WP_006496019.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
L0Y99_RS24955 (L0Y99_24955) 874383..875603 + 1221 WP_205670709.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
L0Y99_RS24960 (L0Y99_24960) 875713..876999 + 1287 WP_006490986.1 DUF445 domain-containing protein -
L0Y99_RS24965 (L0Y99_24965) 877048..877347 - 300 WP_062885379.1 putative addiction module antidote protein Antitoxin
L0Y99_RS24970 (L0Y99_24970) 877351..877689 - 339 WP_276209001.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Y99_RS24975 (L0Y99_24975) 878057..879697 + 1641 WP_006490980.1 acetolactate synthase large subunit -
L0Y99_RS24980 (L0Y99_24980) 879726..881159 + 1434 WP_006490987.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(17-109)

Antitoxin

Uncharacterized protein HI1420

(4-97)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12604.50 Da        Isoelectric Point: 7.8496

>T231595 WP_276209001.1 NZ_CP090677:c877689-877351 [Burkholderia cenocepacia]
MVYTLQCMPYSPPAFGIRTTDVFDAWFAGLPDRLAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYDVRRG
TIWVILLCGGDQSTQQADIRAAHAMLAYLDME

Download         Length: 339 bp

>T231595 NZ_CP126934:c813619-813512 [Escherichia coli O78:H4]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10622.07 Da        Isoelectric Point: 6.4771

>AT231595 WP_062885379.1 NZ_CP090677:c877347-877048 [Burkholderia cenocepacia]
MDKIKTRPWDSAEHLKTEDDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHAAKAAA

Download         Length: 300 bp

>AT231595 NZ_CP126934:813672-813733 [Escherichia coli O78:H4]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References