Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 298595..299232 Replicon chromosome
Accession NZ_CP090676
Organism Burkholderia cenocepacia strain 2019Y71443953II

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Y99_RS05940 Protein ID WP_205671571.1
Coordinates 298595..298996 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A364GPY9
Locus tag L0Y99_RS05945 Protein ID WP_034201144.1
Coordinates 298996..299232 (-) Length 79 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y99_RS05930 (L0Y99_05930) 295979..297109 + 1131 WP_085964363.1 alginate lyase family protein -
L0Y99_RS05935 (L0Y99_05935) 297140..298528 + 1389 WP_077190293.1 L-serine ammonia-lyase -
L0Y99_RS05940 (L0Y99_05940) 298595..298996 - 402 WP_205671571.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Y99_RS05945 (L0Y99_05945) 298996..299232 - 237 WP_034201144.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L0Y99_RS05950 (L0Y99_05950) 299350..299579 - 230 Protein_288 type II toxin-antitoxin system RelE/ParE family toxin -
L0Y99_RS05955 (L0Y99_05955) 299948..301651 + 1704 WP_205671570.1 thiamine pyrophosphate-binding protein -
L0Y99_RS05960 (L0Y99_05960) 301648..302745 + 1098 WP_200063711.1 ADP-heptose--LPS heptosyltransferase -
L0Y99_RS05965 (L0Y99_05965) 302840..303856 - 1017 WP_006493582.1 helix-turn-helix domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-120)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 134 a.a.        Molecular weight: 15039.29 Da        Isoelectric Point: 6.2245

>T231593 WP_205671571.1 NZ_CP090676:c298996-298595 [Burkholderia cenocepacia]
MPRFMLDTNMCIYLMKNQPEQVARRFARCYTGDVVMSAITYAELECGLTACVNPARERRHLAALIEDIPVAPFDAAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLND

Download         Length: 402 bp

>T231593 NZ_CP126932:c147988-147572 [Escherichia coli O78:H51]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8982.15 Da        Isoelectric Point: 6.4701

>AT231593 WP_034201144.1 NZ_CP090676:c299232-298996 [Burkholderia cenocepacia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPMRRPLTQVLAKFAKFGPDFMADGRGDHEQAEREGL

Download         Length: 237 bp

>AT231593 NZ_CP126932:c148215-147985 [Escherichia coli O78:H51]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGACCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A364GPY9

References