231591

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 2107547..2108247 Replicon chromosome
Accession NZ_CP090673
Organism Burkholderia multivorans strain 2020Y71628512IV

Toxin (Protein)


Gene name tad Uniprot ID B9BQB7
Locus tag L0Y82_RS20140 Protein ID WP_006405634.1
Coordinates 2107547..2107924 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID B9BQB8
Locus tag L0Y82_RS20145 Protein ID WP_006405635.1
Coordinates 2107924..2108247 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y82_RS20115 (L0Y82_20120) 2103092..2103538 + 447 WP_006405630.1 VOC family protein -
L0Y82_RS20120 (L0Y82_20125) 2103642..2105192 - 1551 WP_006398698.1 sodium:solute symporter family protein -
L0Y82_RS20125 (L0Y82_20130) 2105189..2105422 - 234 WP_006398697.1 DUF3311 domain-containing protein -
L0Y82_RS20130 (L0Y82_20135) 2105619..2106536 - 918 WP_006405631.1 spermidine synthase -
L0Y82_RS20135 (L0Y82_20140) 2106764..2107018 + 255 WP_035488690.1 hypothetical protein -
L0Y82_RS20140 (L0Y82_20145) 2107547..2107924 + 378 WP_006405634.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L0Y82_RS20145 (L0Y82_20150) 2107924..2108247 + 324 WP_006405635.1 helix-turn-helix transcriptional regulator Antitoxin
L0Y82_RS20150 (L0Y82_20155) 2108270..2108761 - 492 WP_006409760.1 DNA-deoxyinosine glycosylase -
L0Y82_RS20155 (L0Y82_20160) 2108758..2109372 - 615 WP_006398690.1 chorismate lyase -
L0Y82_RS20160 (L0Y82_20165) 2109381..2111279 - 1899 WP_006409758.1 molecular chaperone HtpG -
L0Y82_RS20165 (L0Y82_20170) 2111438..2112898 - 1461 WP_006405639.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(23-114)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13564.63 Da        Isoelectric Point: 9.7722

>T231591 WP_006405634.1 NZ_CP090673:2107547-2107924 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARKHLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGLGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGEK

Download         Length: 378 bp

>T231591 NZ_CP126932:127693-127854 [Escherichia coli O78:H51]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTTGAACCGCCCCGGGTTTCCTGGAGAGTGTTTTATCTGT
GA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11828.69 Da        Isoelectric Point: 8.0686

>AT231591 WP_006405635.1 NZ_CP090673:2107924-2108247 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Download         Length: 324 bp

>AT231591 NZ_CP126932:c127649-127588 [Escherichia coli O78:H51]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B9BQB7

Antitoxin

Source ID Structure
AlphaFold DB B9BQB8

References