Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 1362169..1363208 | Replicon | chromosome |
| Accession | NZ_CP090672 | ||
| Organism | Burkholderia multivorans strain 2020Y71628512IV | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | L0Y82_RS05725 | Protein ID | WP_045593318.1 |
| Coordinates | 1362169..1362744 (-) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | A0A8B3VE28 |
| Locus tag | L0Y82_RS05730 | Protein ID | WP_035946227.1 |
| Coordinates | 1362741..1363208 (-) | Length | 156 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Y82_RS05695 (L0Y82_05695) | 1357596..1358096 | - | 501 | WP_226823143.1 | hypothetical protein | - |
| L0Y82_RS05700 (L0Y82_05700) | 1358110..1359168 | - | 1059 | WP_226823145.1 | DUF6402 family protein | - |
| L0Y82_RS05705 (L0Y82_05705) | 1359552..1359665 | + | 114 | Protein_1134 | porin | - |
| L0Y82_RS05710 (L0Y82_05710) | 1359724..1360689 | - | 966 | WP_006409441.1 | zinc-binding alcohol dehydrogenase family protein | - |
| L0Y82_RS05715 (L0Y82_05715) | 1360768..1361019 | - | 252 | WP_006409444.1 | hypothetical protein | - |
| L0Y82_RS05720 (L0Y82_05720) | 1361115..1361924 | + | 810 | WP_006409450.1 | helix-turn-helix transcriptional regulator | - |
| L0Y82_RS05725 (L0Y82_05725) | 1362169..1362744 | - | 576 | WP_045593318.1 | PIN domain-containing protein | Toxin |
| L0Y82_RS05730 (L0Y82_05730) | 1362741..1363208 | - | 468 | WP_035946227.1 | helix-turn-helix domain-containing protein | Antitoxin |
| L0Y82_RS05735 (L0Y82_05735) | 1363324..1364130 | - | 807 | WP_035487732.1 | 4-hydroxy-2-oxoheptanedioate aldolase | - |
| L0Y82_RS05740 (L0Y82_05740) | 1364138..1364941 | - | 804 | WP_006402377.1 | 2-oxo-hepta-3-ene-1,7-dioic acid hydratase | - |
| L0Y82_RS05745 (L0Y82_05745) | 1364956..1365348 | - | 393 | WP_006409445.1 | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase | - |
| L0Y82_RS05750 (L0Y82_05750) | 1365384..1366232 | - | 849 | WP_006409439.1 | 3,4-dihydroxyphenylacetate 2,3-dioxygenase | - |
| L0Y82_RS05755 (L0Y82_05755) | 1366275..1367738 | - | 1464 | WP_006409448.1 | 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21555.65 Da Isoelectric Point: 4.8924
>T231588 WP_045593318.1 NZ_CP090672:c1362744-1362169 [Burkholderia multivorans]
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLAAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDEFVDDLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL
MTHSPFTAIYDACVLYPAPLRDFLMRLALSGCFRARWSAHITDEWKRNLLDNRPDLTAEQLDRTSSLMDRAIPDAVVTGY
ESLIAGLVLPDADDRHVLAAAIRCNASVIVTFNRKDFPEEALLPYGIEAQHPDEFVDDLFDLEPAVVVAAARRQREALKQ
PPLTADRYLEILRRQGMVQTCQSLDAYRALL
Download Length: 576 bp
>T231588 NZ_CP126931:c4928001-4927690 [Escherichia coli O78:H51]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTATTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTATTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
Antitoxin
Download Length: 156 a.a. Molecular weight: 17655.06 Da Isoelectric Point: 5.8709
>AT231588 WP_035946227.1 NZ_CP090672:c1363208-1362741 [Burkholderia multivorans]
MHHATTPDMILPVEREMQAAVEGQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELSKQAQDLRMGYE
MHHATTPDMILPVEREMQAAVEGQRMLAAYLATRTDTQRIQIFDDENRAHQVELPTSALRLLVDILAELADGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESNALPYHRTGKHRRVRFSDLMRYKAERDQESADAMEELSKQAQDLRMGYE
Download Length: 468 bp
>AT231588 NZ_CP126931:c4927689-4927399 [Escherichia coli O78:H51]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|