Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/- |
Location | 630308..631578 | Replicon | chromosome |
Accession | NZ_CP090672 | ||
Organism | Burkholderia multivorans strain 2020Y71628512IV |
Toxin (Protein)
Gene name | vapC | Uniprot ID | - |
Locus tag | L0Y82_RS02600 | Protein ID | WP_006410613.1 |
Coordinates | 630308..630886 (-) | Length | 193 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | B9BS12 |
Locus tag | L0Y82_RS02605 | Protein ID | WP_006406126.1 |
Coordinates | 631021..631578 (-) | Length | 186 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L0Y82_RS02580 (L0Y82_02580) | 625596..626387 | + | 792 | WP_035947285.1 | enoyl-CoA hydratase | - |
L0Y82_RS02585 (L0Y82_02585) | 626384..627523 | + | 1140 | WP_006410588.1 | enoyl-CoA hydratase/isomerase family protein | - |
L0Y82_RS02590 (L0Y82_02590) | 627570..628490 | - | 921 | WP_006406123.1 | LysR family transcriptional regulator | - |
L0Y82_RS02595 (L0Y82_02595) | 628669..630207 | + | 1539 | WP_006410596.1 | MFS transporter | - |
L0Y82_RS02600 (L0Y82_02600) | 630308..630886 | - | 579 | WP_006410613.1 | HD domain-containing protein | Toxin |
L0Y82_RS02605 (L0Y82_02605) | 631021..631578 | - | 558 | WP_006406126.1 | helix-turn-helix transcriptional regulator | Antitoxin |
L0Y82_RS02610 (L0Y82_02610) | 632091..633494 | + | 1404 | WP_006406128.1 | hypothetical protein | - |
L0Y82_RS02615 (L0Y82_02615) | 633505..634125 | - | 621 | WP_006410617.1 | isochorismatase family cysteine hydrolase | - |
L0Y82_RS02620 (L0Y82_02620) | 634714..635157 | - | 444 | WP_223852633.1 | antibiotic biosynthesis monooxygenase | - |
L0Y82_RS02625 (L0Y82_02625) | 635257..636282 | - | 1026 | WP_006406131.1 | aldo/keto reductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21384.10 Da Isoelectric Point: 4.9434
>T231584 WP_006410613.1 NZ_CP090672:c630886-630308 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
APEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQT
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
APEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQT
Download Length: 579 bp
>T231584 NZ_CP126931:3935649-3935927 [Escherichia coli O78:H51]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA
Antitoxin
Download Length: 186 a.a. Molecular weight: 20378.30 Da Isoelectric Point: 7.8341
>AT231584 WP_006406126.1 NZ_CP090672:c631578-631021 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATAERLLAAHLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATAERLLAAHLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL
Download Length: 558 bp
>AT231584 NZ_CP126931:3935386-3935646 [Escherichia coli O78:H51]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|