231584

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/-
Location 630308..631578 Replicon chromosome
Accession NZ_CP090672
Organism Burkholderia multivorans strain 2020Y71628512IV

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Y82_RS02600 Protein ID WP_006410613.1
Coordinates 630308..630886 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B9BS12
Locus tag L0Y82_RS02605 Protein ID WP_006406126.1
Coordinates 631021..631578 (-) Length 186 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y82_RS02580 (L0Y82_02580) 625596..626387 + 792 WP_035947285.1 enoyl-CoA hydratase -
L0Y82_RS02585 (L0Y82_02585) 626384..627523 + 1140 WP_006410588.1 enoyl-CoA hydratase/isomerase family protein -
L0Y82_RS02590 (L0Y82_02590) 627570..628490 - 921 WP_006406123.1 LysR family transcriptional regulator -
L0Y82_RS02595 (L0Y82_02595) 628669..630207 + 1539 WP_006410596.1 MFS transporter -
L0Y82_RS02600 (L0Y82_02600) 630308..630886 - 579 WP_006410613.1 HD domain-containing protein Toxin
L0Y82_RS02605 (L0Y82_02605) 631021..631578 - 558 WP_006406126.1 helix-turn-helix transcriptional regulator Antitoxin
L0Y82_RS02610 (L0Y82_02610) 632091..633494 + 1404 WP_006406128.1 hypothetical protein -
L0Y82_RS02615 (L0Y82_02615) 633505..634125 - 621 WP_006410617.1 isochorismatase family cysteine hydrolase -
L0Y82_RS02620 (L0Y82_02620) 634714..635157 - 444 WP_223852633.1 antibiotic biosynthesis monooxygenase -
L0Y82_RS02625 (L0Y82_02625) 635257..636282 - 1026 WP_006406131.1 aldo/keto reductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(16-173)

Antitoxin

(12-64)


Sequences


Toxin        


Download         Length: 193 a.a.        Molecular weight: 21384.10 Da        Isoelectric Point: 4.9434

>T231584 WP_006410613.1 NZ_CP090672:c630886-630308 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
APEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQT

Download         Length: 579 bp

>T231584 NZ_CP126931:3935649-3935927 [Escherichia coli O78:H51]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20378.30 Da        Isoelectric Point: 7.8341

>AT231584 WP_006406126.1 NZ_CP090672:c631578-631021 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATAERLLAAHLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSDGSAARLVETL

Download         Length: 558 bp

>AT231584 NZ_CP126931:3935386-3935646 [Escherichia coli O78:H51]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB B9BS12

References