Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 209286..210202 Replicon plasmid pPA1609-475
Accession NZ_CP090650
Organism Pseudomonas aeruginosa strain PA1609

Toxin (Protein)


Gene name slvT Uniprot ID A0A2L1KI32
Locus tag L0026_RS33015 Protein ID WP_019437783.1
Coordinates 209286..209810 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2L1KH13
Locus tag L0026_RS33020 Protein ID WP_019437782.1
Coordinates 209807..210202 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0026_RS32995 (L0026_32980) 204607..205752 + 1146 WP_021263240.1 glycerate kinase -
L0026_RS33000 (L0026_32985) 206172..206363 - 192 WP_019437785.1 hypothetical protein -
L0026_RS33005 (L0026_32990) 206738..207793 + 1056 WP_139139567.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
L0026_RS33010 (L0026_32995) 207990..209240 + 1251 WP_019437784.1 TerD family protein -
L0026_RS33015 (L0026_33000) 209286..209810 - 525 WP_019437783.1 RES family NAD+ phosphorylase Toxin
L0026_RS33020 (L0026_33005) 209807..210202 - 396 WP_019437782.1 hypothetical protein Antitoxin
L0026_RS33025 (L0026_33010) 210786..212669 - 1884 WP_223819158.1 helicase -
L0026_RS33030 (L0026_33015) 212869..213123 + 255 WP_021263738.1 hypothetical protein -
L0026_RS33035 (L0026_33020) 214017..214541 + 525 WP_010794447.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrVC1 / ARR-3 / dfrA22 / qacE / sul1 / mph(E) / msr(E) / armA / blaOXA-1 / blaIMP-45 - 1..475129 475129


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19052.57 Da        Isoelectric Point: 4.5535

>T231583 WP_019437783.1 NZ_CP090650:c209810-209286 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP

Download         Length: 525 bp

>T231583 NZ_CP126931:3732394-3732936 [Escherichia coli O78:H51]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14753.87 Da        Isoelectric Point: 7.2048

>AT231583 WP_019437782.1 NZ_CP090650:c210202-209807 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp

>AT231583 NZ_CP126931:3732099-3732410 [Escherichia coli O78:H51]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L1KI32

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1KH13

References