Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3640003..3641224 Replicon chromosome
Accession NZ_CP090649
Organism Pseudomonas aeruginosa strain PA1609

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0026_RS16815 Protein ID WP_012614272.1
Coordinates 3640646..3641224 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0026_RS16810 Protein ID WP_019396179.1
Coordinates 3640003..3640557 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0026_RS16785 (L0026_16780) 3635571..3636122 + 552 WP_003102727.1 XRE family transcriptional regulator -
L0026_RS16790 (L0026_16785) 3636119..3636517 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
L0026_RS16795 (L0026_16790) 3636530..3636853 - 324 WP_003102734.1 multidrug efflux SMR transporter -
L0026_RS16800 (L0026_16795) 3637184..3637645 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
L0026_RS16805 (L0026_16800) 3637650..3639845 + 2196 WP_014603034.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
L0026_RS16810 (L0026_16805) 3640003..3640557 + 555 WP_019396179.1 helix-turn-helix transcriptional regulator Antitoxin
L0026_RS16815 (L0026_16810) 3640646..3641224 + 579 WP_012614272.1 HD domain-containing protein Toxin
L0026_RS16820 (L0026_16815) 3641333..3642520 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
L0026_RS16825 (L0026_16820) 3642510..3644681 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
L0026_RS16830 (L0026_16825) 3644671..3645948 - 1278 WP_019396178.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21899.72 Da        Isoelectric Point: 5.3655

>T231578 WP_012614272.1 NZ_CP090649:3640646-3641224 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLASLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

>T231578 NZ_CP126931:2216930-2217033 [Escherichia coli O78:H51]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20482.68 Da        Isoelectric Point: 8.1590

>AT231578 WP_019396179.1 NZ_CP090649:3640003-3640557 [Pseudomonas aeruginosa]
MTEPIPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPVRAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT231578 NZ_CP126931:c2217071-2216800 [Escherichia coli O78:H51]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References