Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 147109..147614 Replicon chromosome
Accession NZ_CP090649
Organism Pseudomonas aeruginosa strain PA1609

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag L0026_RS00690 Protein ID WP_003121619.1
Coordinates 147109..147390 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag L0026_RS00695 Protein ID WP_003112628.1
Coordinates 147387..147614 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0026_RS00665 (L0026_00665) 142360..143709 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
L0026_RS00670 (L0026_00670) 143758..144444 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
L0026_RS00675 (L0026_00675) 144545..145279 + 735 WP_003117208.1 GntR family transcriptional regulator -
L0026_RS00680 (L0026_00680) 145459..145869 + 411 WP_003101225.1 aegerolysin family protein -
L0026_RS00685 (L0026_00685) 145901..146809 - 909 WP_016561475.1 LysR family transcriptional regulator -
L0026_RS00690 (L0026_00690) 147109..147390 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
L0026_RS00695 (L0026_00695) 147387..147614 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
L0026_RS00700 (L0026_00700) 147790..148410 - 621 WP_003101226.1 hypothetical protein -
L0026_RS00705 (L0026_00705) 148511..149011 + 501 WP_003112629.1 LEA type 2 family protein -
L0026_RS00710 (L0026_00710) 149084..149425 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
L0026_RS00715 (L0026_00715) 149507..150934 - 1428 WP_003083784.1 GABA permease -
L0026_RS00720 (L0026_00720) 151103..152596 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T231574 WP_003121619.1 NZ_CP090649:c147390-147109 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T231574 NZ_CP126931:1407791-1408189 [Escherichia coli O78:H51]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT231574 WP_003112628.1 NZ_CP090649:c147614-147387 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT231574 NZ_CP126931:1407564-1407791 [Escherichia coli O78:H51]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References