Detailed information of TA system TA231573

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 6237812..6239033
• Replicon: chromosome
• Accession: NZ_CP090648
• Organism: Pseudomonas aeruginosa strain PA1616

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: L0025_RS29055
• Protein ID: WP_003102740.1
• Coordinates: 6238455..6239033 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: L0025_RS29050
• Protein ID: WP_003088112.1
• Coordinates: 6237812..6238366 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0025_RS29025 (L0025_29020)	6233380..6233931	+	552	WP_004343115.1	XRE family transcriptional regulator	-
L0025_RS29030 (L0025_29025)	6233928..6234326	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
L0025_RS29035 (L0025_29030)	6234339..6234662	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
L0025_RS29040 (L0025_29035)	6234993..6235454	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
L0025_RS29045 (L0025_29040)	6235459..6237654	+	2196	WP_010794059.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
L0025_RS29050 (L0025_29045)	6237812..6238366	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
L0025_RS29055 (L0025_29050)	6238455..6239033	+	579	WP_003102740.1	HD domain-containing protein	Toxin
L0025_RS29060 (L0025_29055)	6239142..6240329	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
L0025_RS29065 (L0025_29060)	6240319..6242490	-	2172	WP_003114950.1	type I secretion system permease/ATPase	-
L0025_RS29070 (L0025_29065)	6242480..6243757	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T231573 WP_003102740.1 NZ_CP090648:6238455-6239033 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T231573 NZ_CP126931:1108291-1108626 [Escherichia coli O78:H51]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT231573 WP_003088112.1 NZ_CP090648:6237812-6238366 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT231573 NZ_CP126931:1108043-1108291 [Escherichia coli O78:H51]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07