Detailed information of TA system TA231570

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 2685506..2686011
• Replicon: chromosome
• Accession: NZ_CP090648
• Organism: Pseudomonas aeruginosa strain PA1616

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: L0025_RS12515
• Protein ID: WP_003083773.1
• Coordinates: 2685506..2685787 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: L0025_RS12520
• Protein ID: WP_003083775.1
• Coordinates: 2685784..2686011 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0025_RS12490 (L0025_12490)	2680757..2682106	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
L0025_RS12495 (L0025_12495)	2682155..2682841	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
L0025_RS12500 (L0025_12500)	2682942..2683676	+	735	WP_003117208.1	GntR family transcriptional regulator	-
L0025_RS12505 (L0025_12505)	2683856..2684266	+	411	WP_003101225.1	aegerolysin family protein	-
L0025_RS12510 (L0025_12510)	2684298..2685206	-	909	WP_010793581.1	LysR family transcriptional regulator	-
L0025_RS12515 (L0025_12515)	2685506..2685787	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
L0025_RS12520 (L0025_12520)	2685784..2686011	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
L0025_RS12525 (L0025_12525)	2686187..2686807	-	621	WP_003101226.1	hypothetical protein	-
L0025_RS12530 (L0025_12530)	2686908..2687408	+	501	WP_003101228.1	LEA type 2 family protein	-
L0025_RS12535 (L0025_12535)	2687481..2687822	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
L0025_RS12540 (L0025_12540)	2687904..2689331	-	1428	WP_003083784.1	GABA permease	-
L0025_RS12545 (L0025_12545)	2689500..2690993	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T231570 WP_003083773.1 NZ_CP090648:c2685787-2685506 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T231570 NZ_CP126931:c641054-640590 [Escherichia coli O78:H51]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT231570 WP_003083775.1 NZ_CP090648:c2686011-2685784 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT231570 NZ_CP126931:c641389-641054 [Escherichia coli O78:H51]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9