Detailed information of TA system TA231565

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 1707350..1708608
• Replicon: chromosome
• Accession: NZ_CP090647
• Organism: Pseudomonas aeruginosa strain PA1681

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: L0024_RS08005
• Protein ID: WP_028681273.1
• Coordinates: 1707853..1708608 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: L0024_RS08000
• Protein ID: WP_028681272.1
• Coordinates: 1707350..1707718 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0024_RS07980 (L0024_07980)	1703513..1703788	+	276	WP_010792073.1	zinc ribbon domain-containing protein	-
L0024_RS07985 (L0024_07985)	1703791..1704267	-	477	WP_003112531.1	hypothetical protein	-
L0024_RS07990 (L0024_07990)	1704442..1705935	+	1494	WP_003086325.1	aldehyde dehydrogenase family protein	-
L0024_RS07995 (L0024_07995)	1705991..1707277	+	1287	WP_003163134.1	FAD-binding oxidoreductase	-
L0024_RS08000 (L0024_08000)	1707350..1707718	+	369	WP_028681272.1	DUF2384 domain-containing protein	Antitoxin
L0024_RS08005 (L0024_08005)	1707853..1708608	+	756	WP_028681273.1	RES family NAD+ phosphorylase	Toxin
L0024_RS08010 (L0024_08010)	1709378..1710739	+	1362	WP_003081943.1	DNA recombination protein RmuC	-
L0024_RS08015 (L0024_08015)	1710894..1713437	-	2544	WP_033986314.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28262.43 Da
• Isoelectric Point: 7.7294

>T231565 WP_028681273.1 NZ_CP090647:1707853-1708608 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T231565 NZ_CP126929:c167743-167594 [Escherichia coli O2:K1:H4]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13395.68 Da
• Isoelectric Point: 10.2722

>AT231565 WP_028681272.1 NZ_CP090647:1707350-1707718 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGRVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT231565 NZ_CP126929:167787-167848 [Escherichia coli O2:K1:H4]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT