Detailed information of TA system TA231562

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): chpSB/PRK09812-MazE
• Location: 71252..71847
• Replicon: plasmid unnamed4
• Accession: NZ_CP090646
• Organism: Burkholderia contaminans strain LMG 23361

Toxin (Protein)

• Gene name: chpB
• Uniprot ID: A0A6P2RVL2
• Locus tag: LXE91_RS43585
• Protein ID: WP_039341512.1
• Coordinates: 71497..71847 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: chpS
• Uniprot ID: -
• Locus tag: LXE91_RS43580
• Protein ID: WP_076841588.1
• Coordinates: 71252..71503 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXE91_RS43560 (LXE91_43460)	66992..68275	+	1284	WP_069586065.1	TrbI/VirB10 family protein	-
LXE91_RS43565 (LXE91_43465)	68272..69387	+	1116	WP_069586064.1	P-type DNA transfer ATPase VirB11	-
LXE91_RS43570 (LXE91_43470)	69391..69531	+	141	WP_157644980.1	hypothetical protein	-
LXE91_RS43575 (LXE91_43475)	69564..71045	+	1482	WP_069586063.1	hypothetical protein	-
LXE91_RS43580 (LXE91_43480)	71252..71503	+	252	WP_076841588.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LXE91_RS43585 (LXE91_43485)	71497..71847	+	351	WP_039341512.1	type II toxin-antitoxin system ChpB family toxin	Toxin
LXE91_RS43590 (LXE91_43490)	71860..72102	+	243	WP_039341511.1	hypothetical protein	-
LXE91_RS43595 (LXE91_43495)	72151..72504	+	354	WP_157644981.1	hypothetical protein	-
LXE91_RS43600 (LXE91_43500)	72476..72685	+	210	WP_039341506.1	hypothetical protein	-
LXE91_RS43605 (LXE91_43505)	72757..73431	+	675	WP_076841591.1	hypothetical protein	-
LXE91_RS43610 (LXE91_43510)	73476..73700	+	225	WP_039341503.1	hypothetical protein	-
LXE91_RS43615 (LXE91_43515)	73771..74133	+	363	WP_069586060.1	hypothetical protein	-
LXE91_RS43620 (LXE91_43520)	74142..74372	+	231	WP_083268473.1	hypothetical protein	-
LXE91_RS43625 (LXE91_43525)	74522..74935	+	414	WP_069586059.1	hypothetical protein	-
LXE91_RS43630	74987..75109	+	123	WP_256103105.1	hypothetical protein	-
LXE91_RS43635 (LXE91_43530)	75213..75677	+	465	WP_039341501.1	hypothetical protein	-
LXE91_RS43640 (LXE91_43535)	75693..76238	+	546	WP_175035022.1	phospholipase D family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..76682	76682

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (7-116)

Antitoxin

• Antitoxin PemI-like (1-83)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12400.34 Da
• Isoelectric Point: 8.6851

>T231562 WP_039341512.1 NZ_CP090646:71497-71847 [Burkholderia contaminans]
MVRRVKFERGDIVRVSLNPTIGKEQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARYAGFAVPLSGAGTETQGVALV
NMVRTLDLEARGARKVERAPVEVVEDALARLQTILE

Nucleotide

• Length: 351 bp

>T231562 NZ_CP126929:37113-37529 [Escherichia coli O2:K1:H4]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 8904.14 Da
• Isoelectric Point: 4.9679

>AT231562 WP_076841588.1 NZ_CP090646:71252-71503 [Burkholderia contaminans]
MELKIQKWGNSAAVRLPAVLLEQIGASAGSSLNADVRPDGVLLTPARRKYSLDELVAQCDQNAPQPADLAAWVEAKPVGH
EAW

Nucleotide

• Length: 252 bp

>AT231562 NZ_CP126929:36886-37116 [Escherichia coli O2:K1:H4]
ATGAGAACCGTATCTATTTTCAAAAATGGAAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA

Structures

Toxin

• AlphaFold DB: A0A6P2RVL2