Detailed information of TA system TA231560

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 80100..80758
• Replicon: plasmid unnamed3
• Accession: NZ_CP090645
• Organism: Burkholderia contaminans strain LMG 23361

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LXE91_RS42690
• Protein ID: WP_069301955.1
• Coordinates: 80100..80531 (-)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LXE91_RS42695
• Protein ID: WP_069301954.1
• Coordinates: 80531..80758 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXE91_RS42655 (LXE91_42560)	76181..76354	-	174	WP_174990676.1	hypothetical protein	-
LXE91_RS42660 (LXE91_42565)	76500..76874	-	375	WP_069301959.1	hypothetical protein	-
LXE91_RS42665 (LXE91_42570)	76871..77611	-	741	WP_069301958.1	hypothetical protein	-
LXE91_RS42670 (LXE91_42575)	77626..78711	-	1086	WP_069301957.1	hypothetical protein	-
LXE91_RS42675 (LXE91_42580)	78759..78932	-	174	WP_174990675.1	hypothetical protein	-
LXE91_RS42680 (LXE91_42585)	78946..79656	-	711	WP_083264182.1	helix-turn-helix domain-containing protein	-
LXE91_RS42685 (LXE91_42590)	79752..80078	-	327	WP_141716973.1	hypothetical protein	-
LXE91_RS42690 (LXE91_42595)	80100..80531	-	432	WP_069301955.1	PIN domain-containing protein	Toxin
LXE91_RS42695 (LXE91_42600)	80531..80758	-	228	WP_069301954.1	CopG family transcriptional regulator	Antitoxin
LXE91_RS42700 (LXE91_42605)	81117..82325	+	1209	WP_070162840.1	hypothetical protein	-
LXE91_RS42705 (LXE91_42610)	82415..82657	+	243	WP_069301913.1	hypothetical protein	-
LXE91_RS42710 (LXE91_42615)	82783..83187	+	405	WP_141716963.1	hypothetical protein	-
LXE91_RS42715 (LXE91_42620)	83228..83797	+	570	WP_141716964.1	hypothetical protein	-
LXE91_RS42720 (LXE91_42625)	83794..84231	+	438	WP_069301916.1	hypothetical protein	-
LXE91_RS42725 (LXE91_42630)	84278..84418	-	141	WP_174990674.1	hypothetical protein	-
LXE91_RS42730 (LXE91_42635)	84527..85447	-	921	WP_069301917.1	hypothetical protein	-
LXE91_RS42735 (LXE91_42640)	85444..85725	-	282	WP_069301918.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..162811	162811

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-127)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15621.98 Da
• Isoelectric Point: 7.1847

>T231560 WP_069301955.1 NZ_CP090645:c80531-80100 [Burkholderia contaminans]
MTYLLDVNVLIALLDPAHVQHEPAHAWFGRVGYAAWSTCPLTENGVLRIIGNPKYPNTMGSPASVAPLVAQLRAHAGHTF
WPDDVSLLDEKHVDATRLLSSAQLTDTYLLALARVHKGKLATFDRRLVVDAVPNGAKHLELIS

Nucleotide

• Length: 432 bp

>T231560 NZ_CP126928:c4691278-4690967 [Escherichia coli O2:K1:H4]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8066.16 Da
• Isoelectric Point: 10.6932

>AT231560 WP_069301954.1 NZ_CP090645:c80758-80531 [Burkholderia contaminans]
MRTTIDIDDDILALARARAKPGTSIGKVISELARAALQRTTTNQTSRNGLPLMPTSATARSVTLDTVNQLRDDSL

Nucleotide

• Length: 228 bp

>AT231560 NZ_CP126928:c4690966-4690676 [Escherichia coli O2:K1:H4]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG