Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 65594..66188 Replicon plasmid unnamed2
Accession NZ_CP090644
Organism Burkholderia contaminans strain LMG 23361

Toxin (Protein)


Gene name PumA Uniprot ID A0A228JB64
Locus tag LXE91_RS41490 Protein ID WP_027811055.1
Coordinates 65594..65887 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A228JAU5
Locus tag LXE91_RS41495 Protein ID WP_027811056.1
Coordinates 65889..66188 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE91_RS41465 (LXE91_41370) 60908..63187 + 2280 WP_278068198.1 ParB/RepB/Spo0J family partition protein -
LXE91_RS41470 (LXE91_41375) 64231..64497 + 267 WP_027811052.1 hypothetical protein -
LXE91_RS41475 (LXE91_41380) 64472..65023 + 552 WP_077186813.1 hypothetical protein -
LXE91_RS41480 (LXE91_41385) 65068..65289 + 222 WP_027811054.1 DUF3717 domain-containing protein -
LXE91_RS41485 (LXE91_41390) 65346..65489 + 144 WP_154233621.1 hypothetical protein -
LXE91_RS41490 (LXE91_41395) 65594..65887 + 294 WP_027811055.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXE91_RS41495 (LXE91_41400) 65889..66188 + 300 WP_027811056.1 putative addiction module antidote protein Antitoxin
LXE91_RS41500 (LXE91_41405) 66351..66662 - 312 WP_027811057.1 hypothetical protein -
LXE91_RS41505 (LXE91_41410) 66910..67410 - 501 WP_278068199.1 hypothetical protein -
LXE91_RS41510 (LXE91_41415) 68427..68828 + 402 WP_027811058.1 hypothetical protein -
LXE91_RS41515 (LXE91_41420) 68821..70887 + 2067 WP_027811059.1 type IV secretion system DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..199797 199797


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-87)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10854.50 Da        Isoelectric Point: 10.6086

>T231558 WP_027811055.1 NZ_CP090644:65594-65887 [Burkholderia contaminans]
MRIEQTDDFAKWLRGLRDHIARAQIAKRIQRLARGQYGDMKPVGAGVSEMRVHVGPGYRVYFVQRGSTLVVLLCGGDKST
QQRDIERAIALSAQLGD

Download         Length: 294 bp

>T231558 NZ_CP126928:4149823-4150080 [Escherichia coli O2:K1:H4]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10716.01 Da        Isoelectric Point: 4.6364

>AT231558 WP_027811056.1 NZ_CP090644:65889-66188 [Burkholderia contaminans]
MGIKTTPFDAAEYLDTPEAQAEYLRISFETGDSADIQEAIGTVARARGMTQIARDAGVGRESLYKALDEHGNPEFATILR
VVRALGLTLTVTTPVHEHA

Download         Length: 300 bp

>AT231558 NZ_CP126928:4150092-4150637 [Escherichia coli O2:K1:H4]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCGGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCTTTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A228JB64

Antitoxin

Source ID Structure
AlphaFold DB A0A228JAU5

References