Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 1034127..1034722 Replicon chromosome
Accession NZ_CP090642
Organism Burkholderia contaminans strain LMG 23361

Toxin (Protein)


Gene name chpB Uniprot ID A0A1E3FP25
Locus tag LXE91_RS36755 Protein ID WP_039362634.1
Coordinates 1034127..1034477 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A0G3Z282
Locus tag LXE91_RS36760 Protein ID WP_039362633.1
Coordinates 1034471..1034722 (-) Length 84 a.a.

Genomic Context

LXE91_RS36745LXE91_RS36750LXE91_RS36765LXE91_RS36755LXE91_RS36760LXE91_RS36770LXE91_RS36775
Location: 1030982..1032442 (1461 bp)
Type: Others
Protein ID: WP_039362635.1
Location: 1032474..1034003 (1530 bp)
Type: Others
Protein ID: WP_039362750.1
Location: 1035255..1037075 (1821 bp)
Type: Others
Protein ID: WP_046197074.1
Location: 1034127..1034477 (351 bp)
Type: Toxin
Protein ID: WP_039362634.1
Location: 1034471..1034722 (252 bp)
Type: Antitoxin
Protein ID: WP_039362633.1
Location: 1037307..1038767 (1461 bp)
Type: Others
Protein ID: WP_039362631.1
Location: 1038764..1039441 (678 bp)
Type: Others
Protein ID: WP_039362629.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LXE91_RS36745 (LXE91_36670)1030982..1032442+1461WP_039362635.1efflux RND transporter periplasmic adaptor subunit-
LXE91_RS36750 (LXE91_36675)1032474..1034003+1530WP_039362750.1efflux transporter outer membrane subunit-
LXE91_RS36755 (LXE91_36680)1034127..1034477-351WP_039362634.1type II toxin-antitoxin system ChpB family toxinToxin
LXE91_RS36760 (LXE91_36685)1034471..1034722-252WP_039362633.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
LXE91_RS36765 (LXE91_36690)1035255..1037075+1821WP_046197074.1asparagine synthase (glutamine-hydrolyzing)-
LXE91_RS36770 (LXE91_36695)1037307..1038767-1461WP_039362631.1heavy metal sensor histidine kinase-
LXE91_RS36775 (LXE91_36700)1038764..1039441-678WP_039362629.1heavy metal response regulator transcription factor-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12403.30 Da        Isoelectric Point: 10.0752

>T231557 WP_039362634.1 NZ_CP090642:c1034477-1034127 [Burkholderia contaminans]
MVRRVKFERGDIVRVSLNPTVGKEQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARYAGFAVPLSGSGTETQGVALV
NMVRTLDLQARGARKVERAPSEVIEDALARLQTILE

Download         Length: 351 bp

>T231557 NZ_CP126928:4112637-4112978 [Escherichia coli O2:K1:H4]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCACTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACTGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTCGCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8948.19 Da        Isoelectric Point: 4.7204

>AT231557 WP_039362633.1 NZ_CP090642:c1034722-1034471 [Burkholderia contaminans]
MELKIQKWGNSAAVRLPAVLLEQIDASVGSSLNADVRPDGVLLSPARRKYSLDELIAQCDPKAPEPADLAAWGESKPVGH
EAW

Download         Length: 252 bp

>AT231557 NZ_CP126928:c4112642-4112566 [Escherichia coli O2:K1:H4]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1E3FP25

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0G3Z282

References