Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 1034127..1034722 Replicon chromosome
Accession NZ_CP090642
Organism Burkholderia contaminans strain LMG 23361

Toxin (Protein)


Gene name chpB Uniprot ID A0A1E3FP25
Locus tag LXE91_RS36755 Protein ID WP_039362634.1
Coordinates 1034127..1034477 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A0G3Z282
Locus tag LXE91_RS36760 Protein ID WP_039362633.1
Coordinates 1034471..1034722 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE91_RS36745 (LXE91_36670) 1030982..1032442 + 1461 WP_039362635.1 efflux RND transporter periplasmic adaptor subunit -
LXE91_RS36750 (LXE91_36675) 1032474..1034003 + 1530 WP_039362750.1 efflux transporter outer membrane subunit -
LXE91_RS36755 (LXE91_36680) 1034127..1034477 - 351 WP_039362634.1 type II toxin-antitoxin system ChpB family toxin Toxin
LXE91_RS36760 (LXE91_36685) 1034471..1034722 - 252 WP_039362633.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LXE91_RS36765 (LXE91_36690) 1035255..1037075 + 1821 WP_046197074.1 asparagine synthase (glutamine-hydrolyzing) -
LXE91_RS36770 (LXE91_36695) 1037307..1038767 - 1461 WP_039362631.1 heavy metal sensor histidine kinase -
LXE91_RS36775 (LXE91_36700) 1038764..1039441 - 678 WP_039362629.1 heavy metal response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12403.30 Da        Isoelectric Point: 10.0752

>T231557 WP_039362634.1 NZ_CP090642:c1034477-1034127 [Burkholderia contaminans]
MVRRVKFERGDIVRVSLNPTVGKEQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARYAGFAVPLSGSGTETQGVALV
NMVRTLDLQARGARKVERAPSEVIEDALARLQTILE

Download         Length: 351 bp

>T231557 NZ_CP126928:4112637-4112978 [Escherichia coli O2:K1:H4]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCACTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACTGCGGTAGATGTCAAAGTAATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTCGCCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8948.19 Da        Isoelectric Point: 4.7204

>AT231557 WP_039362633.1 NZ_CP090642:c1034722-1034471 [Burkholderia contaminans]
MELKIQKWGNSAAVRLPAVLLEQIDASVGSSLNADVRPDGVLLSPARRKYSLDELIAQCDPKAPEPADLAAWGESKPVGH
EAW

Download         Length: 252 bp

>AT231557 NZ_CP126928:c4112642-4112566 [Escherichia coli O2:K1:H4]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FP25

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3Z282

References