Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2624558..2625199 Replicon chromosome
Accession NZ_CP090641
Organism Burkholderia contaminans strain LMG 23361

Toxin (Protein)


Gene name relE Uniprot ID A0A1E3FZX6
Locus tag LXE91_RS29490 Protein ID WP_039344753.1
Coordinates 2624861..2625199 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1J9PWC2
Locus tag LXE91_RS29485 Protein ID WP_039344756.1
Coordinates 2624558..2624857 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE91_RS29460 (LXE91_29380) 2619721..2620992 + 1272 WP_039344770.1 anthranilate 1,2-dioxygenase large subunit AndAc -
LXE91_RS29465 (LXE91_29385) 2621007..2621495 + 489 WP_011355917.1 anthranilate 1,2-dioxygenase small subunit AndAd -
LXE91_RS29470 (LXE91_29390) 2621516..2621842 + 327 WP_039344765.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
LXE91_RS29475 (LXE91_29395) 2621832..2623052 + 1221 WP_039344761.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
LXE91_RS29480 (LXE91_29400) 2623223..2624509 + 1287 WP_039344759.1 DUF445 domain-containing protein -
LXE91_RS29485 (LXE91_29405) 2624558..2624857 - 300 WP_039344756.1 putative addiction module antidote protein Antitoxin
LXE91_RS29490 (LXE91_29410) 2624861..2625199 - 339 WP_039344753.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXE91_RS29495 (LXE91_29415) 2625531..2627171 + 1641 WP_039344750.1 acetolactate synthase large subunit -
LXE91_RS29500 (LXE91_29420) 2627201..2628634 + 1434 WP_039344747.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(16-107)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12583.47 Da        Isoelectric Point: 9.5691

>T231556 WP_039344753.1 NZ_CP090641:c2625199-2624861 [Burkholderia contaminans]
MVDILQSMPYSAPTFSIRTTGVFDTWFAGLQDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRG
TIWVILLCGGDKSSQQADIRAAHAMLAHLDME

Download         Length: 339 bp

>T231556 NZ_CP126928:4032055-4032207 [Escherichia coli O2:K1:H4]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10649.01 Da        Isoelectric Point: 6.3217

>AT231556 WP_039344756.1 NZ_CP090641:c2624857-2624558 [Burkholderia contaminans]
MDKISTRPWDSADHLKTEDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHA

Download         Length: 300 bp

>AT231556 NZ_CP126928:c4032006-4031949 [Escherichia coli O2:K1:H4]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FZX6

Antitoxin

Source ID Structure
AlphaFold DB A0A1J9PWC2

References