Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1560443..1560962 Replicon chromosome
Accession NZ_CP090641
Organism Burkholderia contaminans strain LMG 23361

Toxin (Protein)


Gene name relE Uniprot ID A0A1E3FLI5
Locus tag LXE91_RS24665 Protein ID WP_039349649.1
Coordinates 1560443..1560724 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4V2WFY1
Locus tag LXE91_RS24670 Protein ID WP_039349647.1
Coordinates 1560714..1560962 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE91_RS24645 (LXE91_24570) 1556098..1556796 - 699 WP_039349658.1 MgtC/SapB family protein -
LXE91_RS24650 (LXE91_24575) 1556911..1558020 + 1110 WP_039349656.1 AGE family epimerase/isomerase -
LXE91_RS24655 (LXE91_24580) 1557993..1559612 - 1620 WP_039349654.1 methyl-accepting chemotaxis protein -
LXE91_RS24660 (LXE91_24585) 1559882..1560325 + 444 WP_011353771.1 PaaI family thioesterase -
LXE91_RS24665 (LXE91_24590) 1560443..1560724 - 282 WP_039349649.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXE91_RS24670 (LXE91_24595) 1560714..1560962 - 249 WP_039349647.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LXE91_RS24675 (LXE91_24600) 1561104..1562156 - 1053 WP_039349645.1 CaiB/BaiF CoA-transferase family protein -
LXE91_RS24680 (LXE91_24605) 1562340..1563530 - 1191 WP_039349643.1 2-methylaconitate cis-trans isomerase PrpF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-78)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10986.88 Da        Isoelectric Point: 10.7091

>T231555 WP_039349649.1 NZ_CP090641:c1560724-1560443 [Burkholderia contaminans]
MTFELAFLEPALKEWKKLDRTVRDQFKSRLAERLENPRIPSAKLQGHPDRYKIKLRSVGYRLVYEVRDSEVLVLVVAVGR
RERDAVYLAAMKR

Download         Length: 282 bp

>T231555 NZ_CP126928:3701591-3701989 [Escherichia coli O2:K1:H4]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9031.44 Da        Isoelectric Point: 5.6792

>AT231555 WP_039349647.1 NZ_CP090641:c1560962-1560714 [Burkholderia contaminans]
MPHTILANVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALADKRAKEKVVKVKLN
DL

Download         Length: 249 bp

>AT231555 NZ_CP126928:3701295-3701588 [Escherichia coli O2:K1:H4]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FLI5

Antitoxin

Source ID Structure
AlphaFold DB A0A4V2WFY1

References