Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 522007..523757 Replicon chromosome
Accession NZ_CP090641
Organism Burkholderia contaminans strain LMG 23361

Toxin (Protein)


Gene name doc Uniprot ID A0A1E3FSX8
Locus tag LXE91_RS20075 Protein ID WP_039344096.1
Coordinates 522861..523757 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1E3FSY5
Locus tag LXE91_RS20070 Protein ID WP_039344097.1
Coordinates 522007..522864 (-) Length 286 a.a.

Genomic Context

LXE91_RS20105LXE91_RS20050LXE91_RS20055LXE91_RS20060LXE91_RS20065LXE91_RS20070LXE91_RS20075LXE91_RS20080LXE91_RS20085LXE91_RS20090LXE91_RS20095LXE91_RS20100
Location: 527308..528387 (1080 bp)
Type: Others
Protein ID: WP_039344086.1
Location: 517170..518660 (1491 bp)
Type: Others
Protein ID: WP_039344105.1
Location: 518733..519560 (828 bp)
Type: Others
Protein ID: WP_039344103.1
Location: 519553..521220 (1668 bp)
Type: Others
Protein ID: WP_039344101.1
Location: 521213..522010 (798 bp)
Type: Others
Protein ID: WP_039344099.1
Location: 522007..522864 (858 bp)
Type: Antitoxin
Protein ID: WP_039344097.1
Location: 522861..523757 (897 bp)
Type: Toxin
Protein ID: WP_039344096.1
Location: 523776..524303 (528 bp)
Type: Others
Protein ID: WP_039344094.1
Location: 524341..525111 (771 bp)
Type: Others
Protein ID: WP_039344092.1
Location: 525104..526180 (1077 bp)
Type: Others
Protein ID: WP_039344090.1
Location: 526233..526544 (312 bp)
Type: Others
Protein ID: WP_039344088.1
Location: 526546..526863 (318 bp)
Type: Others
Protein ID: WP_011354710.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LXE91_RS20050 (LXE91_19975)517170..518660-1491WP_039344105.1aldehyde dehydrogenase-
LXE91_RS20055 (LXE91_19980)518733..519560-828WP_039344103.1aspartate dehydrogenase-
LXE91_RS20060 (LXE91_19985)519553..521220-1668WP_039344101.1thiamine pyrophosphate-binding protein-
LXE91_RS20065 (LXE91_19990)521213..522010-798WP_039344099.1SDR family oxidoreductase-
LXE91_RS20070 (LXE91_19995)522007..522864-858WP_039344097.1IclR family transcriptional regulatorAntitoxin
LXE91_RS20075 (LXE91_20000)522861..523757-897WP_039344096.1alpha/beta fold hydrolaseToxin
LXE91_RS20080 (LXE91_20005)523776..524303-528WP_039344094.1cupin domain-containing protein-
LXE91_RS20085 (LXE91_20010)524341..525111-771WP_039344092.1SDR family oxidoreductase-
LXE91_RS20090 (LXE91_20015)525104..526180-1077WP_039344090.1aromatic ring-hydroxylating dioxygenase subunit alpha-
LXE91_RS20095 (LXE91_20020)526233..526544-312WP_039344088.1hypothetical protein-
LXE91_RS20100 (LXE91_20025)526546..526863-318WP_011354710.1non-heme iron oxygenase ferredoxin subunit-
LXE91_RS20105 (LXE91_20030)527308..528387+1080WP_039344086.1porin-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30700.99 Da        Isoelectric Point: 8.0624

>T231554 WP_039344096.1 NZ_CP090641:c523757-522861 [Burkholderia contaminans]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAHHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLIRVMPARIAGLLLVSPAGGYGSAPAETR
DARRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATQLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDAFCRQCDQQRGLA

Download         Length: 897 bp

>T231554 NZ_CP126928:3559307-3559525 [Escherichia coli O2:K1:H4]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGTCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31463.03 Da        Isoelectric Point: 6.7661

>AT231554 WP_039344097.1 NZ_CP090641:c522864-522007 [Burkholderia contaminans]
MNEPLQRPELENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT231554 NZ_CP126928:3558907-3559281 [Escherichia coli O2:K1:H4]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1E3FSX8

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1E3FSY5

References