Detailed information of TA system TA231553

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 241035..241674
• Replicon: chromosome
• Accession: NZ_CP090641
• Organism: Burkholderia contaminans strain LMG 23361

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LXE91_RS18890
• Protein ID: WP_223274309.1
• Coordinates: 241035..241451 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1X1PQC0
• Locus tag: LXE91_RS18895
• Protein ID: WP_039351245.1
• Coordinates: 241438..241674 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXE91_RS18865 (LXE91_18795)	236202..237290	-	1089	WP_039350864.1	nitronate monooxygenase	-
LXE91_RS18870 (LXE91_18800)	237287..238219	-	933	WP_039350867.1	enoyl-CoA hydratase	-
LXE91_RS18875 (LXE91_18805)	238228..239025	-	798	WP_039350869.1	ketoacid CoA transferase	-
LXE91_RS18880 (LXE91_18810)	239036..239929	-	894	WP_039350872.1	CoA-transferase	-
LXE91_RS18885 (LXE91_18815)	239939..240835	-	897	WP_039350875.1	VOC family protein	-
LXE91_RS18890 (LXE91_18820)	241035..241451	-	417	WP_223274309.1	type II toxin-antitoxin system VapC family toxin	Toxin
LXE91_RS18895 (LXE91_18825)	241438..241674	-	237	WP_039351245.1	DNA-binding protein	Antitoxin
LXE91_RS18900 (LXE91_18830)	242048..242707	-	660	WP_046196544.1	hypothetical protein	-
LXE91_RS18905 (LXE91_18835)	243500..244273	-	774	WP_039351252.1	SDR family oxidoreductase	-
LXE91_RS18910 (LXE91_18840)	244312..245892	-	1581	WP_039350882.1	FadD3 family acyl-CoA ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15370.68 Da
• Isoelectric Point: 7.4021

>T231553 WP_223274309.1 NZ_CP090641:c241451-241035 [Burkholderia contaminans]
VYLIDTNIISEIRKGKRTNRGVRAFFRQAAADASPLYLSVVTVAELRRGVDLIRHRGDHPQASALEAWMATILSGYAPNI
LPVDIEISQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVEDFARTGVKLLNPFD

Nucleotide

• Length: 417 bp

>T231553 NZ_CP126928:c3530184-3529882 [Escherichia coli O2:K1:H4]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATTGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8598.61 Da
• Isoelectric Point: 5.0477

>AT231553 WP_039351245.1 NZ_CP090641:c241674-241438 [Burkholderia contaminans]
MANLLVRNVDDSIVQSLREQAAANGRSAEAEHRAILADALGRPKRKTFAQVLMSMPDVGDDADFQRVQDSGEARRVFD

Nucleotide

• Length: 237 bp

>AT231553 NZ_CP126928:c3529846-3529505 [Escherichia coli O2:K1:H4]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Structures

Antitoxin

• AlphaFold DB: A0A1X1PQC0