Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2965370..2965900 Replicon chromosome
Accession NZ_CP090640
Organism Burkholderia contaminans strain LMG 23361

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag LXE91_RS13775 Protein ID WP_232490759.1
Coordinates 2965661..2965900 (+) Length 80 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag LXE91_RS13770 Protein ID WP_076841742.1
Coordinates 2965370..2965615 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE91_RS13735 (LXE91_13685) 2960435..2961451 + 1017 WP_039358635.1 GNAT family N-acetyltransferase -
LXE91_RS13740 (LXE91_13690) 2961701..2961967 + 267 WP_046196769.1 type II toxin-antitoxin system VapB family antitoxin -
LXE91_RS13745 (LXE91_13695) 2961964..2962125 + 162 WP_223274361.1 type II toxin-antitoxin system VapC family toxin -
LXE91_RS13750 (LXE91_13700) 2962153..2962380 + 228 WP_223274360.1 hypothetical protein -
LXE91_RS13755 (LXE91_13705) 2962429..2962668 - 240 Protein_2689 nucleotidyltransferase -
LXE91_RS13760 (LXE91_13710) 2962682..2963770 - 1089 WP_249215684.1 type IV toxin-antitoxin system AbiEi family antitoxin -
LXE91_RS13765 (LXE91_13715) 2964090..2965253 + 1164 WP_039358627.1 M20 aminoacylase family protein -
LXE91_RS13770 (LXE91_13720) 2965370..2965615 + 246 WP_076841742.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LXE91_RS13775 (LXE91_13725) 2965661..2965900 + 240 WP_232490759.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXE91_RS13780 (LXE91_13730) 2965971..2967275 - 1305 WP_039358619.1 cobyrinate a,c-diamide synthase -
LXE91_RS13785 (LXE91_13735) 2967278..2967880 - 603 WP_039358616.1 cob(I)yrinic acid a,c-diamide adenosyltransferase -
LXE91_RS13790 (LXE91_13740) 2967918..2968295 - 378 WP_039358613.1 cobalamin biosynthesis protein -
LXE91_RS13795 (LXE91_13745) 2968292..2969041 - 750 WP_039358610.1 uroporphyrinogen-III C-methyltransferase -
LXE91_RS13800 (LXE91_13750) 2969746..2970660 + 915 WP_278068087.1 CSS-motif domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(1-74)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 80 a.a.        Molecular weight: 9325.66 Da        Isoelectric Point: 8.0671

>T231551 WP_232490759.1 NZ_CP090640:2965661-2965900 [Burkholderia contaminans]
IWRDTVGRGSLKQTDLYHRDLIGTMEALARGEKVGRTCIVRDGYFRYAVGSHVVFYRETEYTIDLIRVLHQRMDIEQHL

Download         Length: 240 bp

>T231551 NZ_CP126928:c2433554-2432232 [Escherichia coli O2:K1:H4]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGAGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAATGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCAAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACAGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTATGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9021.01 Da        Isoelectric Point: 5.6864

>AT231551 WP_076841742.1 NZ_CP090640:2965370-2965615 [Burkholderia contaminans]
MSQNASVSRRDHFAELVDTQVQSEQYGSASDVERTGLRLLESRDMQVRALQEALKAGEVSGALRPFDREAFLARMRAAHD
G

Download         Length: 246 bp

>AT231551 NZ_CP126928:c2433820-2433554 [Escherichia coli O2:K1:H4]
ATGATGAGCTTTCAGAAGATCTATAGCCCAATGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTAACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCAAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References