Detailed information of TA system TA231550

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VagC(antitoxin)
• Location: 2961701..2962125
• Replicon: chromosome
• Accession: NZ_CP090640
• Organism: Burkholderia contaminans strain LMG 23361

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: -
• Locus tag: LXE91_RS13745
• Protein ID: WP_223274361.1
• Coordinates: 2961964..2962125 (+)
• Length: 54 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A1E3FFT1
• Locus tag: LXE91_RS13740
• Protein ID: WP_046196769.1
• Coordinates: 2961701..2961967 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXE91_RS13725 (LXE91_13675)	2957248..2959509	+	2262	WP_039358640.1	TonB-dependent siderophore receptor	-
LXE91_RS13730 (LXE91_13680)	2959596..2960435	+	840	WP_039358638.1	N(5)-hydroxyornithine transformylase PvdF	-
LXE91_RS13735 (LXE91_13685)	2960435..2961451	+	1017	WP_039358635.1	GNAT family N-acetyltransferase	-
LXE91_RS13740 (LXE91_13690)	2961701..2961967	+	267	WP_046196769.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LXE91_RS13745 (LXE91_13695)	2961964..2962125	+	162	WP_223274361.1	type II toxin-antitoxin system VapC family toxin	Toxin
LXE91_RS13750 (LXE91_13700)	2962153..2962380	+	228	WP_223274360.1	hypothetical protein	-
LXE91_RS13755 (LXE91_13705)	2962429..2962668	-	240	Protein_2689	nucleotidyltransferase	-
LXE91_RS13760 (LXE91_13710)	2962682..2963770	-	1089	WP_249215684.1	type IV toxin-antitoxin system AbiEi family antitoxin	-
LXE91_RS13765 (LXE91_13715)	2964090..2965253	+	1164	WP_039358627.1	M20 aminoacylase family protein	-
LXE91_RS13770 (LXE91_13720)	2965370..2965615	+	246	WP_076841742.1	type II toxin-antitoxin system ParD family antitoxin	-
LXE91_RS13775 (LXE91_13725)	2965661..2965900	+	240	WP_232490759.1	type II toxin-antitoxin system RelE/ParE family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• SpoVT-AbrB domain (7-50)

Sequences

Toxin

Protein

• Length: 54 a.a.
• Molecular weight: 5903.95 Da
• Isoelectric Point: 8.5349

>T231550 WP_223274361.1 NZ_CP090640:2961964-2962125 [Burkholderia contaminans]
VTTLYMLDTSICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAAG

Nucleotide

• Length: 162 bp

>T231550 NZ_CP126928:c2397094-2396816 [Escherichia coli O2:K1:H4]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9629.86 Da
• Isoelectric Point: 4.4819

>AT231550 WP_046196769.1 NZ_CP090640:2961701-2961967 [Burkholderia contaminans]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTCLSFASEPPADADFLAERPAVIEPGRFDLSDGGG
AAPTESGQ

Nucleotide

• Length: 267 bp

>AT231550 NZ_CP126928:c2396816-2396532 [Escherichia coli O2:K1:H4]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCAGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTTTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCGGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Structures

Antitoxin

• AlphaFold DB: A0A1E3FFT1