Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 1213901..1214538 Replicon chromosome
Accession NZ_CP090640
Organism Burkholderia contaminans strain LMG 23361

Toxin (Protein)


Gene name vapC Uniprot ID A0A228K4S8
Locus tag LXE91_RS05630 Protein ID WP_039351354.1
Coordinates 1214137..1214538 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A1E3FXY0
Locus tag LXE91_RS05625 Protein ID WP_039351357.1
Coordinates 1213901..1214137 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE91_RS05610 (LXE91_05590) 1209594..1210625 + 1032 WP_039351365.1 helix-turn-helix domain-containing protein -
LXE91_RS05615 (LXE91_05595) 1210743..1211840 - 1098 WP_039351363.1 ADP-heptose--LPS heptosyltransferase -
LXE91_RS05620 (LXE91_05600) 1211837..1213540 - 1704 WP_039351360.1 thiamine pyrophosphate-binding protein -
LXE91_RS05625 (LXE91_05605) 1213901..1214137 + 237 WP_039351357.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LXE91_RS05630 (LXE91_05610) 1214137..1214538 + 402 WP_039351354.1 type II toxin-antitoxin system VapC family toxin Toxin
LXE91_RS05635 (LXE91_05615) 1214609..1215997 - 1389 WP_039351351.1 L-serine ammonia-lyase -
LXE91_RS05640 (LXE91_05620) 1216028..1217131 - 1104 WP_223274380.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14880.98 Da        Isoelectric Point: 4.7249

>T231549 WP_039351354.1 NZ_CP090640:1214137-1214538 [Burkholderia contaminans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVAACASPARERGNLAALIDDIPVAPFDVAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLDD

Download         Length: 402 bp

>T231549 NZ_CP126928:c2120948-2120841 [Escherichia coli O2:K1:H4]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9008.13 Da        Isoelectric Point: 6.4720

>AT231549 WP_039351357.1 NZ_CP090640:1213901-1214137 [Burkholderia contaminans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTRVLEKFAKFGPDFMADGRGDHEQADREGL

Download         Length: 237 bp

>AT231549 NZ_CP126928:2121001-2121062 [Escherichia coli O2:K1:H4]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A228K4S8

Antitoxin

Source ID Structure
AlphaFold DB A0A1E3FXY0

References