Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1-VagC |
| Location | 89078..89727 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP090638 | ||
| Organism | Burkholderia contaminans strain FFI45 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | LXE92_RS39450 | Protein ID | WP_027813527.1 |
| Coordinates | 89317..89727 (+) | Length | 137 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | A0A6P2T8K5 |
| Locus tag | LXE92_RS39445 | Protein ID | WP_027813526.1 |
| Coordinates | 89078..89320 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LXE92_RS39425 (LXE92_39380) | 84295..85152 | - | 858 | WP_027813522.1 | plasmid replication initiator TrfA | - |
| LXE92_RS39430 (LXE92_39385) | 85895..86860 | - | 966 | WP_027813523.1 | ParB/RepB/Spo0J family partition protein | - |
| LXE92_RS39435 (LXE92_39390) | 86860..87531 | - | 672 | WP_027813524.1 | AAA family ATPase | - |
| LXE92_RS39440 (LXE92_39395) | 87997..88983 | + | 987 | WP_223274426.1 | non-homologous end-joining DNA ligase | - |
| LXE92_RS39445 (LXE92_39400) | 89078..89320 | + | 243 | WP_027813526.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
| LXE92_RS39450 (LXE92_39405) | 89317..89727 | + | 411 | WP_027813527.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LXE92_RS39455 (LXE92_39410) | 90027..90386 | + | 360 | WP_223274427.1 | hypothetical protein | - |
| LXE92_RS39460 (LXE92_39415) | 90435..90635 | + | 201 | WP_034176085.1 | hypothetical protein | - |
| LXE92_RS39465 (LXE92_39420) | 90823..91476 | + | 654 | WP_027813530.1 | helix-turn-helix domain-containing protein | - |
| LXE92_RS39470 (LXE92_39425) | 91497..91802 | + | 306 | WP_027813531.1 | hypothetical protein | - |
| LXE92_RS39475 (LXE92_39430) | 91847..92932 | + | 1086 | WP_027813532.1 | hypothetical protein | - |
| LXE92_RS39480 (LXE92_39435) | 92943..93173 | + | 231 | WP_027813533.1 | hypothetical protein | - |
| LXE92_RS39485 (LXE92_39440) | 93183..93437 | + | 255 | WP_046544062.1 | hypothetical protein | - |
| LXE92_RS39490 (LXE92_39445) | 93653..94324 | + | 672 | WP_034176084.1 | hypothetical protein | - |
| LXE92_RS39495 (LXE92_39450) | 94406..94696 | + | 291 | WP_027813562.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..198595 | 198595 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 137 a.a. Molecular weight: 14869.13 Da Isoelectric Point: 4.8604
>T231548 WP_027813527.1 NZ_CP090638:89317-89727 [Burkholderia contaminans]
MTLYLLDTNILSNVIRDPRGACATRIGETPPEQVCTSIIVAAELRFGVWKRGSSTLAQRVEQLLASLTVLPLQPDADRCY
GRLRAELEKQGQLIDANDMLIAAHALAVDAVLVTDNTAEFTRIAGLPVENWLRPAT
MTLYLLDTNILSNVIRDPRGACATRIGETPPEQVCTSIIVAAELRFGVWKRGSSTLAQRVEQLLASLTVLPLQPDADRCY
GRLRAELEKQGQLIDANDMLIAAHALAVDAVLVTDNTAEFTRIAGLPVENWLRPAT
Download Length: 411 bp
>T231548 NZ_CP126928:c1941417-1941043 [Escherichia coli O2:K1:H4]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9375.64 Da Isoelectric Point: 4.6856
>AT231548 WP_027813526.1 NZ_CP090638:89078-89320 [Burkholderia contaminans]
MPNHDTRHARLFRNGRSQAVRIPREFELPVSEVTIHREGRRLIIEPVEAAPLRELFAQWTPLDEIFPDIEDLPPEPVDIE
MPNHDTRHARLFRNGRSQAVRIPREFELPVSEVTIHREGRRLIIEPVEAAPLRELFAQWTPLDEIFPDIEDLPPEPVDIE
Download Length: 243 bp
>AT231548 NZ_CP126928:c1941874-1941506 [Escherichia coli O2:K1:H4]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|