Detailed information of TA system TA231544

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2758086..2758701
• Replicon: chromosome
• Accession: NZ_CP090636
• Organism: Burkholderia contaminans strain FFI45

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LXE92_RS29765
• Protein ID: WP_278131643.1
• Coordinates: 2758086..2758328 (-)
• Length: 81 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LXE92_RS29770
• Protein ID: WP_278131644.1
• Coordinates: 2758459..2758701 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXE92_RS29755 (LXE92_29690)	2755732..2757462	-	1731	WP_039357257.1	cation acetate symporter	-
LXE92_RS29760 (LXE92_29695)	2757459..2757767	-	309	WP_039357260.1	DUF485 domain-containing protein	-
LXE92_RS29765 (LXE92_29700)	2758086..2758328	-	243	WP_278131643.1	PIN domain-containing protein	Toxin
LXE92_RS29770 (LXE92_29705)	2758459..2758701	-	243	WP_278131644.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LXE92_RS29775 (LXE92_29710)	2758916..2759599	+	684	WP_278131646.1	phospholipase	-
LXE92_RS29780 (LXE92_29715)	2759661..2761172	-	1512	WP_039357269.1	amino acid permease	-
LXE92_RS29785 (LXE92_29720)	2761281..2762687	-	1407	WP_105816113.1	aspartate ammonia-lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (6-66)

Antitoxin

• SpoVT-AbrB domain (9-53)

Sequences

Toxin

Protein

• Length: 81 a.a.
• Molecular weight: 8711.90 Da
• Isoelectric Point: 6.2138

>T231544 WP_278131643.1 NZ_CP090636:c2758328-2758086 [Burkholderia contaminans]
VARVEALQFEVVSFDVEDARHAGAIRAHPTAVGTPIGPYDALIAGQARARPLVLVTHNVREFARVPGLQVEDWLAKARED

Nucleotide

• Length: 243 bp

>T231544 NZ_CP126928:947958-948365 [Escherichia coli O2:K1:H4]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8677.75 Da
• Isoelectric Point: 4.6982

>AT231544 WP_278131644.1 NZ_CP090636:c2758701-2758459 [Burkholderia contaminans]
MDTARIFEHGGSQAVLLPKEFRFETTEVRIRRHGSSVILEPVPQGGAWLTPLIGPVDADFEAATTTGPAAQQRSGLDVFE

Nucleotide

• Length: 243 bp

>AT231544 NZ_CP126928:947711-947977 [Escherichia coli O2:K1:H4]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA