Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2204645..2205284 Replicon chromosome
Accession NZ_CP090636
Organism Burkholderia contaminans strain FFI45

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LXE92_RS27315 Protein ID WP_278133563.1
Coordinates 2204868..2205284 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X1PQC0
Locus tag LXE92_RS27310 Protein ID WP_039351245.1
Coordinates 2204645..2204881 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE92_RS27290 (LXE92_27220) 2200426..2202006 + 1581 WP_278131100.1 FadD3 family acyl-CoA ligase -
LXE92_RS27295 (LXE92_27225) 2202045..2202818 + 774 WP_278131102.1 SDR family oxidoreductase -
LXE92_RS27300 (LXE92_27230) 2202974..2203126 + 153 WP_278131104.1 hypothetical protein -
LXE92_RS27305 (LXE92_27235) 2203612..2204271 + 660 WP_046196544.1 hypothetical protein -
LXE92_RS27310 (LXE92_27240) 2204645..2204881 + 237 WP_039351245.1 DNA-binding protein Antitoxin
LXE92_RS27315 (LXE92_27245) 2204868..2205284 + 417 WP_278133563.1 type II toxin-antitoxin system VapC family toxin Toxin
LXE92_RS27320 (LXE92_27250) 2205484..2206380 + 897 WP_039350875.1 VOC family protein -
LXE92_RS27325 (LXE92_27255) 2206390..2207283 + 894 WP_278131105.1 CoA-transferase -
LXE92_RS27330 (LXE92_27260) 2207294..2208091 + 798 WP_278131106.1 ketoacid CoA transferase -
LXE92_RS27335 (LXE92_27265) 2208100..2209038 + 939 WP_278131108.1 enoyl-CoA hydratase -
LXE92_RS27340 (LXE92_27270) 2209035..2210123 + 1089 WP_278131109.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15354.72 Da        Isoelectric Point: 8.5735

>T231542 WP_278133563.1 NZ_CP090636:2204868-2205284 [Burkholderia contaminans]
VYLIDTNIISEIRKGKRTNRGVRAFFRQAAADASPLYLSVVTVAELRRGVDLIRHRGDHPQASALEAWMATILSGYAPNI
LPVDIEISQMWGHLRVPEPTHELDKLIAATALINDLTVVTRNVVDFARTGVKLLNPFD

Download         Length: 417 bp

>T231542 NZ_CP126928:189781-189888 [Escherichia coli O2:K1:H4]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8598.61 Da        Isoelectric Point: 5.0477

>AT231542 WP_039351245.1 NZ_CP090636:2204645-2204881 [Burkholderia contaminans]
MANLLVRNVDDSIVQSLREQAAANGRSAEAEHRAILADALGRPKRKTFAQVLMSMPDVGDDADFQRVQDSGEARRVFD

Download         Length: 237 bp

>AT231542 NZ_CP126928:c189724-189667 [Escherichia coli O2:K1:H4]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1PQC0

References