Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1949756..1951506 Replicon chromosome
Accession NZ_CP090636
Organism Burkholderia contaminans strain FFI45

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag LXE92_RS26245 Protein ID WP_278130876.1
Coordinates 1949756..1950652 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag LXE92_RS26250 Protein ID WP_278130878.1
Coordinates 1950649..1951506 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE92_RS26215 (LXE92_26145) 1945126..1946205 - 1080 WP_278130871.1 porin -
LXE92_RS26220 (LXE92_26150) 1946650..1946967 + 318 WP_278130872.1 non-heme iron oxygenase ferredoxin subunit -
LXE92_RS26225 (LXE92_26155) 1946969..1947280 + 312 WP_039344088.1 hypothetical protein -
LXE92_RS26230 (LXE92_26160) 1947333..1948409 + 1077 WP_039344090.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
LXE92_RS26235 (LXE92_26165) 1948402..1949172 + 771 WP_278130874.1 SDR family oxidoreductase -
LXE92_RS26240 (LXE92_26170) 1949210..1949737 + 528 WP_039344094.1 cupin domain-containing protein -
LXE92_RS26245 (LXE92_26175) 1949756..1950652 + 897 WP_278130876.1 alpha/beta fold hydrolase Toxin
LXE92_RS26250 (LXE92_26180) 1950649..1951506 + 858 WP_278130878.1 IclR family transcriptional regulator Antitoxin
LXE92_RS26255 (LXE92_26185) 1951503..1952300 + 798 WP_278130879.1 SDR family oxidoreductase -
LXE92_RS26260 (LXE92_26190) 1952293..1953960 + 1668 WP_278130881.1 thiamine pyrophosphate-binding protein -
LXE92_RS26265 (LXE92_26195) 1953953..1954780 + 828 WP_278130883.1 aspartate dehydrogenase -
LXE92_RS26270 (LXE92_26200) 1954853..1956343 + 1491 WP_039344105.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30716.99 Da        Isoelectric Point: 8.0624

>T231541 WP_278130876.1 NZ_CP090636:1949756-1950652 [Burkholderia contaminans]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAHHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLIRVMPARIAGLLLVSPAGGYGSAPAETR
DARRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARVVPAGYAQATQLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDQQRGLA

Download         Length: 897 bp

>T231541 NZ_CP126928:189298-189405 [Escherichia coli O2:K1:H4]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCACGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31436.00 Da        Isoelectric Point: 6.7661

>AT231541 WP_278130878.1 NZ_CP090636:1950649-1951506 [Burkholderia contaminans]
MNEPLQRPELESGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT231541 NZ_CP126928:c189249-189184 [Escherichia coli O2:K1:H4]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References