Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1745083..1745738 Replicon chromosome
Accession NZ_CP090636
Organism Burkholderia contaminans strain FFI45

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LXE92_RS25350 Protein ID WP_071332240.1
Coordinates 1745319..1745738 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LXE92_RS25345 Protein ID WP_105818099.1
Coordinates 1745083..1745322 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE92_RS25320 (LXE92_25250) 1740336..1740731 - 396 WP_039361042.1 type II toxin-antitoxin system VapC family toxin -
LXE92_RS25325 (LXE92_25255) 1740728..1740967 - 240 WP_010089452.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LXE92_RS25330 (LXE92_25260) 1741065..1741748 - 684 WP_278130671.1 Fe2+-dependent dioxygenase -
LXE92_RS25335 (LXE92_25265) 1741745..1742524 - 780 WP_278130673.1 tetratricopeptide repeat protein -
LXE92_RS25340 (LXE92_25270) 1742528..1744771 - 2244 WP_278130674.1 TonB-dependent siderophore receptor -
LXE92_RS25345 (LXE92_25275) 1745083..1745322 + 240 WP_105818099.1 Arc family DNA-binding protein Antitoxin
LXE92_RS25350 (LXE92_25280) 1745319..1745738 + 420 WP_071332240.1 type II toxin-antitoxin system VapC family toxin Toxin
LXE92_RS25355 (LXE92_25285) 1745856..1747151 - 1296 WP_039360985.1 aspartate carbamoyltransferase -
LXE92_RS25360 (LXE92_25290) 1747385..1747519 + 135 WP_006485835.1 entericidin A/B family lipoprotein -
LXE92_RS25365 (LXE92_25295) 1747619..1748167 - 549 WP_278130675.1 permease -
LXE92_RS25370 (LXE92_25300) 1748376..1749344 - 969 WP_278130676.1 DMT family transporter -
LXE92_RS25375 (LXE92_25305) 1749544..1750338 - 795 WP_278130677.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15151.41 Da        Isoelectric Point: 5.7471

>T231540 WP_071332240.1 NZ_CP090636:1745319-1745738 [Burkholderia contaminans]
MILVDTNVMSEPLRREPSTAVIEWLDAQNVETLFLAAISLGEMRFGVAALPEGRRRDWLHHSIEQRVVPLFRGRILPFDD
AASKAYASIRARARASGSAIAPADVFIAATAEANGLIIATRDVAPFEAVGLRVIDPWAS

Download         Length: 420 bp

>T231540 NZ_CP126928:188816-188923 [Escherichia coli O2:K1:H4]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8762.03 Da        Isoelectric Point: 6.4684

>AT231540 WP_105818099.1 NZ_CP090636:1745083-1745322 [Burkholderia contaminans]
MPVITVRNLPDEVHRALRVRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTLLAEIGREAGGVEFDVRRDKTLTDPMSFE

Download         Length: 240 bp

>AT231540 NZ_CP126928:c188759-188702 [Escherichia coli O2:K1:H4]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References