Detailed information of TA system TA231539

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 1650354..1650877
• Replicon: chromosome
• Accession: NZ_CP090636
• Organism: Burkholderia contaminans strain FFI45

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LXE92_RS24950
• Protein ID: WP_174936993.1
• Coordinates: 1650354..1650620 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A228PFA0
• Locus tag: LXE92_RS24955
• Protein ID: WP_060968669.1
• Coordinates: 1650617..1650877 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXE92_RS24925 (LXE92_24855)	1645517..1646755	-	1239	WP_278130597.1	diaminopimelate decarboxylase	-
LXE92_RS24930 (LXE92_24860)	1646865..1647779	+	915	WP_105818132.1	LysR family transcriptional regulator	-
LXE92_RS24935 (LXE92_24865)	1647858..1648457	+	600	WP_278130599.1	GNAT family protein	-
LXE92_RS24940 (LXE92_24870)	1648571..1649149	-	579	WP_039360813.1	DUF4142 domain-containing protein	-
LXE92_RS24945 (LXE92_24875)	1649558..1650181	-	624	WP_278130600.1	HAD hydrolase-like protein	-
LXE92_RS24950 (LXE92_24880)	1650354..1650620	-	267	WP_174936993.1	Txe/YoeB family addiction module toxin	Toxin
LXE92_RS24955 (LXE92_24885)	1650617..1650877	-	261	WP_060968669.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LXE92_RS24960 (LXE92_24890)	1651105..1651548	+	444	WP_039360818.1	GNAT family N-acetyltransferase	-
LXE92_RS24965 (LXE92_24895)	1651606..1651824	+	219	WP_006480837.1	DUF1653 domain-containing protein	-
LXE92_RS24970 (LXE92_24900)	1651876..1653090	-	1215	WP_278130605.1	crosslink repair DNA glycosylase YcaQ family protein	-
LXE92_RS24975 (LXE92_24905)	1653424..1654494	-	1071	WP_278130606.1	terpene synthase	-
LXE92_RS24980 (LXE92_24910)	1654548..1655318	-	771	WP_071332206.1	polyprenyl diphosphate synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10500.78 Da
• Isoelectric Point: 7.9861

>T231539 WP_174936993.1 NZ_CP090636:c1650620-1650354 [Burkholderia contaminans]
MSVRRVLFTSDAWDDYVYWQGQDRKTLKRINQLIREAQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDSQISI
VSCRYHYE

Nucleotide

• Length: 267 bp

>T231539 NZ_CP126927:153493-153891 [Escherichia coli O2:K1:H5]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATGAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9686.96 Da
• Isoelectric Point: 6.4808

>AT231539 WP_060968669.1 NZ_CP090636:c1650877-1650617 [Burkholderia contaminans]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LAADDE

Nucleotide

• Length: 261 bp

>AT231539 NZ_CP126927:153266-153493 [Escherichia coli O2:K1:H5]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGACATGCAGGAAAGGGAGTCATTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A228PFA0