Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 917150..917669 Replicon chromosome
Accession NZ_CP090636
Organism Burkholderia contaminans strain FFI45

Toxin (Protein)


Gene name relE Uniprot ID A0A1E3FLI5
Locus tag LXE92_RS21735 Protein ID WP_039349649.1
Coordinates 917388..917669 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4V2WFY1
Locus tag LXE92_RS21730 Protein ID WP_039349647.1
Coordinates 917150..917398 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXE92_RS21720 (LXE92_21660) 914582..915772 + 1191 WP_046548712.1 2-methylaconitate cis-trans isomerase PrpF -
LXE92_RS21725 (LXE92_21665) 915956..917008 + 1053 WP_278132880.1 CaiB/BaiF CoA-transferase family protein -
LXE92_RS21730 (LXE92_21670) 917150..917398 + 249 WP_039349647.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LXE92_RS21735 (LXE92_21675) 917388..917669 + 282 WP_039349649.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXE92_RS21740 (LXE92_21680) 917787..918230 - 444 WP_011353771.1 PaaI family thioesterase -
LXE92_RS21745 (LXE92_21685) 918500..920119 + 1620 WP_278132882.1 methyl-accepting chemotaxis protein -
LXE92_RS21750 (LXE92_21690) 920092..921201 - 1110 WP_278132884.1 AGE family epimerase/isomerase -
LXE92_RS21755 (LXE92_21695) 921316..922014 + 699 WP_278132887.1 MgtC/SapB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-78)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10986.88 Da        Isoelectric Point: 10.7091

>T231538 WP_039349649.1 NZ_CP090636:917388-917669 [Burkholderia contaminans]
MTFELAFLEPALKEWKKLDRTVRDQFKSRLAERLENPRIPSAKLQGHPDRYKIKLRSVGYRLVYEVRDSEVLVLVVAVGR
RERDAVYLAAMKR

Download         Length: 282 bp

>T231538 NZ_CP126927:c141830-141681 [Escherichia coli O2:K1:H5]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9031.44 Da        Isoelectric Point: 5.6792

>AT231538 WP_039349647.1 NZ_CP090636:917150-917398 [Burkholderia contaminans]
MPHTILANVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALADKRAKEKVVKVKLN
DL

Download         Length: 249 bp

>AT231538 NZ_CP126927:141874-141935 [Escherichia coli O2:K1:H5]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FLI5

Antitoxin

Source ID Structure
AlphaFold DB A0A4V2WFY1

References