Detailed information of TA system TA231537

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 110653..111461
• Replicon: chromosome
• Accession: NZ_CP090636
• Organism: Burkholderia contaminans strain FFI45

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: A0A228GL99
• Locus tag: LXE92_RS18165
• Protein ID: WP_071333118.1
• Coordinates: 110653..111159 (-)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: -
• Locus tag: LXE92_RS18170
• Protein ID: WP_071333119.1
• Coordinates: 111156..111461 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LXE92_RS18140 (LXE92_18080)	105665..106258	+	594	WP_278132158.1	peroxidase-related enzyme	-
LXE92_RS18145 (LXE92_18085)	106366..107103	-	738	WP_278132159.1	isoprenylcysteine carboxylmethyltransferase family protein	-
LXE92_RS18150 (LXE92_18090)	107470..107901	-	432	WP_039354504.1	Lrp/AsnC family transcriptional regulator	-
LXE92_RS18155 (LXE92_18095)	108250..109329	+	1080	WP_278132162.1	ornithine cyclodeaminase	-
LXE92_RS18160 (LXE92_18100)	109389..110402	+	1014	WP_278132164.1	arginine deiminase-related protein	-
LXE92_RS18165 (LXE92_18105)	110653..111159	-	507	WP_071333118.1	GNAT family N-acetyltransferase	Toxin
LXE92_RS18170 (LXE92_18110)	111156..111461	-	306	WP_071333119.1	DUF1778 domain-containing protein	Antitoxin
LXE92_RS18175 (LXE92_18115)	111715..114455	-	2741	Protein_100	hsp70 family protein	-
LXE92_RS18180 (LXE92_18120)	114461..116302	-	1842	WP_278132168.1	Hsp70 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (47-148)

Antitoxin

• Vibrio phage ICP1, Orf50 (1-94)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 18160.89 Da
• Isoelectric Point: 9.0370

>T231537 WP_071333118.1 NZ_CP090636:c111159-110653 [Burkholderia contaminans]
MTLRAPTPITLEHAQAGALDAFDSGEPNLDDWLKRRALRNHVSGASRTFVVCDDQRVVAYYALASGAVDVAAAPGRFRRN
MPDPVPVVVLARLAVDRAWQGRGLGRGLLRDAGLRVMQAADTIGIRGLLAHALSADAQRFYLQVGFEPSPLDPMTVMITL
TDLRASLT

Nucleotide

• Length: 507 bp

>T231537 NZ_CP126927:c138298-138011 [Escherichia coli O2:K1:H5]
ATGACTTATACAGTAAAATTCAGGGATGATGCGCTCAAAGAATGGCTGAAACTGGATAAATCCATTCAACAGCAGTTTGC
GAAAAAACTAAAGAAATGCAGCGAAAATCCTCATATTCCTTCCGCAAAACTGCGTGGATTAAAAGACTGCTACAAAATCA
AACTTCGCGCATCGGGGTTTCGTCTGGTCTATCAGGTTATTGATGACATGCTAATTATTGCGGTTGTCGCGGTAGGTAAA
CGTGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 10902.24 Da
• Isoelectric Point: 8.7713

>AT231537 WP_071333119.1 NZ_CP090636:c111461-111156 [Burkholderia contaminans]
MSATHSPPTKRDTLNLRVQPDERNLIDRAAAARGQNRTDFILSAARAAAEETLLEATLVRASPDAYAAFVARLDAPPAPN
PQLRRTMRTPAPWDGSADPVA

Nucleotide

• Length: 306 bp

>AT231537 NZ_CP126927:c138546-138295 [Escherichia coli O2:K1:H5]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTATCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCGGAACTCTATGAAAGGATGC
TTGATGCGCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTGGAC
AGTTATTTATGA

Structures

Toxin

• AlphaFold DB: A0A228GL99